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G protein-coupled receptor 3
Identifiers
Symbols GPR3; ACCA
External IDs OMIM600241 MGI101908 HomoloGene31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
RNA expression pattern
PBB GE GPR3 214613 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2827 14748
Ensembl ENSG00000181773 ENSMUSG00000049649
UniProt P46089 Q3USD4
RefSeq (mRNA) NM_005281 NM_008154
RefSeq (protein) NP_005272 NP_032180
Location (UCSC) Chr 1:
27.59 - 27.59 Mb
Chr 4:
132.48 - 132.48 Mb
PubMed search [1] [2]

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[1][2][1] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function

GPR3 activates adenylate cyclase in the absence of ligand.[3] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[4] While GPR3 have a certain level of constitutive activity, it is believed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are ligands that further activate the receptor.[5]

References

  1. ^ a b Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics 23 (3): 609-18. doi:10.1006/geno.1994.1549. PMID 7851889.  
  2. ^ "Entrez Gene: GPR3 G protein-coupled receptor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2827.  
  3. ^ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3): 837–43. PMID 7639700.  
  4. ^ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science (journal) 306 (5703): 1947–50. doi:10.1126/science.1103974. PMID 15591206.  
  5. ^ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830.  

Further reading

  • Eggerickx D, Denef JF, Labbe O, et al. (1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.". Biochem. J. 309 ( Pt 3): 837–43. PMID 7639700.  
  • Iismaa TP, Kiefer J, Liu ML, et al. (1995). "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system.". Genomics 24 (2): 391–4. doi:10.1006/geno.1994.1635. PMID 7698767.  
  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.  
  • Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.". Genomics 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
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