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G protein-coupled receptor 3
Symbols GPR3; ACCA
External IDs OMIM600241 MGI101908 HomoloGene31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
RNA expression pattern
PBB GE GPR3 214613 at tn.png
More reference expression data
Species Human Mouse
Entrez 2827 14748
Ensembl ENSG00000181773 ENSMUSG00000049649
UniProt P46089 Q3USD4
RefSeq (mRNA) NM_005281 NM_008154
RefSeq (protein) NP_005272 NP_032180
Location (UCSC) Chr 1:
27.59 - 27.59 Mb
Chr 4:
132.48 - 132.48 Mb
PubMed search [1] [2]

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[1][2][1] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.


GPR3 activates adenylate cyclase in the absence of ligand.[3] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[4] While GPR3 have a certain level of constitutive activity, it is believed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are ligands that further activate the receptor.[5]


  1. ^ a b Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics 23 (3): 609-18. doi:10.1006/geno.1994.1549. PMID 7851889.  
  2. ^ "Entrez Gene: GPR3 G protein-coupled receptor 3".  
  3. ^ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3): 837–43. PMID 7639700.  
  4. ^ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science (journal) 306 (5703): 1947–50. doi:10.1126/science.1103974. PMID 15591206.  
  5. ^ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830.  

Further reading

  • Eggerickx D, Denef JF, Labbe O, et al. (1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.". Biochem. J. 309 ( Pt 3): 837–43. PMID 7639700.  
  • Iismaa TP, Kiefer J, Liu ML, et al. (1995). "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system.". Genomics 24 (2): 391–4. doi:10.1006/geno.1994.1635. PMID 7698767.  
  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.  
  • Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.". Genomics 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  


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