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G protein-coupled receptor 34
Symbols GPR34;
External IDs OMIM300241 MGI1346334 HomoloGene36174 IUPHAR: GPR34 GeneCards: GPR34 Gene
Species Human Mouse
Entrez 2857 23890
Ensembl ENSG00000171659 ENSMUSG00000040229
UniProt Q9UPC5 Q3USC5
RefSeq (mRNA) NM_001033513 NM_011823
RefSeq (protein) NP_001028685 NP_035953
Location (UCSC) Chr X:
41.43 - 41.44 Mb
Chr X:
12.79 - 12.8 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[1][2][3]

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][3]


  1. ^ Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (Aug 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochim Biophys Acta 1446 (1-2): 57-70. PMID 10395919.  
  2. ^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics 56 (1): 12-21. doi:10.1006/geno.1998.5655. PMID 10036181.  
  3. ^ a b "Entrez Gene: GPR34 G protein-coupled receptor 34".  

Further reading

  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Jacobi FK, Broghammer M, Pesch K, et al. (2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.". Hum. Genet. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.". Genomics 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.  
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.  


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