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G protein-coupled receptor 37 (endothelin receptor type B-like)
Identifiers
Symbols GPR37; EDNRBL; PAELR; hET(B)R-LP
External IDs OMIM602583 MGI1313297 HomoloGene3875 IUPHAR: GPR37 GeneCards: GPR37 Gene
RNA expression pattern
PBB GE GPR37 209631 s at tn.png
PBB GE GPR37 214586 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2861 14763
Ensembl ENSG00000170775 ENSMUSG00000039904
UniProt O15354 Q9QY42
RefSeq (mRNA) NM_005302 NM_010338
RefSeq (protein) NP_005293 NP_034468
Location (UCSC) Chr 7:
124.17 - 124.19 Mb
Chr 6:
25.62 - 25.64 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.[1][2]

Interactions

GPR37 has been shown to interact with HSPA1A[3] and Parkin (ligase).[4][3]

References

  1. ^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (Nov 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.  
  2. ^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2861.  
  3. ^ a b Imai, Yuzuru; Soda Mariko, Hatakeyama Shigetsugu, Akagi Takumi, Hashikawa Tsutomu, Nakayama Kei Ichi, Takahashi Ryosuke (Jul. 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell (United States) 10 (1): 55–67. ISSN 1097-2765. PMID 12150907.  
  4. ^ Imai, Y; Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (Jun. 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell (United States) 105 (7): 891–902. ISSN 0092-8674. PMID 11439185.  

Further reading

  • Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain.". Biochem. Biophys. Res. Commun. 233 (2): 559–67. doi:10.1006/bbrc.1997.6408. PMID 9144577.  
  • Donohue PJ, Shapira H, Mantey SA, et al. (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.". Brain Res. Mol. Brain Res. 54 (1): 152–60. doi:10.1016/S0169-328X(97)00336-7. PMID 9526070.  
  • Imai Y, Soda M, Inoue H, et al. (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.". Cell 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.  
  • Imai Y, Soda M, Hatakeyama S, et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.". Mol. Cell 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Yang Y, Nishimura I, Imai Y, et al. (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.". Neuron 37 (6): 911–24. doi:10.1016/S0896-6273(03)00143-0. PMID 12670421.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kubota K, Niinuma Y, Kaneko M, et al. (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.". J. Neurochem. 97 (5): 1259–68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.  
  • Omura T, Kaneko M, Okuma Y, et al. (2007). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.". J. Neurochem. 99 (6): 1456–69. doi:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.  
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