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GPR39: Wikis


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G protein-coupled receptor 39
Symbols GPR39; MGC149541
External IDs OMIM602886 MGI1918361 HomoloGene20380 IUPHAR: GPR39 GeneCards: GPR39 Gene
RNA expression pattern
PBB GE GPR39 208600 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2863 71111
Ensembl ENSG00000183840 ENSMUSG00000026343
UniProt O43194 Q9D442
RefSeq (mRNA) NM_001508 XM_913690
RefSeq (protein) NP_001499 XP_918783
Location (UCSC) Chr 2:
132.89 - 133.12 Mb
Chr 1:
127.5 - 127.7 Mb
PubMed search [1] [2]

G-protein coupled receptor 39 is a protein that in humans is encoded by the GPR39 gene.[1][2]


  1. ^ McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (Mar 1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors". Genomics 46 (3): 426-34. doi:10.1006/geno.1997.5069. PMID 9441746.  
  2. ^ "Entrez Gene: GPR39 G protein-coupled receptor 39".  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Holst B, Holliday ND, Bach A, et al. (2005). "Common structural basis for constitutive activity of the ghrelin receptor family.". J. Biol. Chem. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Holst B, Egerod KL, Schild E, et al. (2007). "GPR39 signaling is stimulated by zinc ions but not by obestatin.". Endocrinology 148 (1): 13–20. doi:10.1210/en.2006-0933. PMID 16959833.  
  • Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39.". Biochem. Biophys. Res. Commun. 351 (1): 21–5. doi:10.1016/j.bbrc.2006.09.141. PMID 17054911.  
  • Egerod KL, Holst B, Petersen PS, et al. (2007). "GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.". Mol. Endocrinol. 21 (7): 1685–98. doi:10.1210/me.2007-0055. PMID 17488974.  
  • Yasuda S, Miyazaki T, Munechika K, et al. (2007). "Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.". J. Recept. Signal Transduct. Res. 27 (4): 235–46. doi:10.1080/10799890701506147. PMID 17885920.  


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