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G protein-coupled receptor 44
Symbols GPR44; CD294; CRTH2
External IDs OMIM604837 MGI1330275 HomoloGene3508 IUPHAR: DP2 GeneCards: GPR44 Gene
RNA expression pattern
PBB GE GPR44 206361 at tn.png
PBB GE GPR44 216464 x at tn.png
More reference expression data
Species Human Mouse
Entrez 11251 14764
Ensembl ENSG00000183134 ENSMUSG00000034117
UniProt Q9Y5Y4 Q54A00
RefSeq (mRNA) NM_004778 NM_009962
RefSeq (protein) NP_004769 NP_034092
Location (UCSC) Chr 11:
60.37 - 60.38 Mb
Chr 19:
11 - 11.01 Mb
PubMed search [1] [2]

G protein-coupled receptor 44 (GPR44) is a human protein.[1] GPR44 has also been designated as CD294 (cluster of differentiation 294).

G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][1]

GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature.


Further reading

  • Nagata K (2004). "CRTH2.". J. Biol. Regul. Homeost. Agents 17 (4): 334–7. PMID 15065763.  
  • Chiba T, Kanda A, Ueki S, et al. (2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells.". Int. Arch. Allergy Immunol. 143 Suppl 1: 23–7. doi:10.1159/000101400. PMID 17541272.  
  • Nagata K, Tanaka K, Ogawa K, et al. (1999). "Selective expression of a novel surface molecule by human Th2 cells in vivo.". J. Immunol. 162 (3): 1278–86. PMID 9973380.  
  • Marchese A, Sawzdargo M, Nguyen T, et al. (1999). "Discovery of three novel orphan G-protein-coupled receptors.". Genomics 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.  
  • Hirai H, Tanaka K, Yoshie O, et al. (2001). "Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.". J. Exp. Med. 193 (2): 255–61. doi:10.1084/jem.193.2.255. PMID 11208866.  
  • Hirai H, Tanaka K, Takano S, et al. (2002). "Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2.". J. Immunol. 168 (3): 981–5. PMID 11801628.  
  • Iwasaki M, Nagata K, Takano S, et al. (2002). "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis.". J. Invest. Dermatol. 119 (3): 609–16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Böhm E, Sturm GJ, Weiglhofer I, et al. (2004). "11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.". J. Biol. Chem. 279 (9): 7663–70. doi:10.1074/jbc.M310270200. PMID 14668348.  
  • Huang JL, Gao PS, Mathias RA, et al. (2005). "Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability.". Hum. Mol. Genet. 13 (21): 2691–7. doi:10.1093/hmg/ddh279. PMID 15345705.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Venet F, Lepape A, Debard AL, et al. (2004). "The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock.". Clin. Immunol. 113 (3): 278–84. doi:10.1016/j.clim.2004.07.005. PMID 15507393.  
  • Gazi L, Gyles S, Rose J, et al. (2005). "Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.". Prostaglandins Other Lipid Mediat. 75 (1-4): 153–67. doi:10.1016/j.prostaglandins.2004.11.003. PMID 15789622.  
  • Hata AN, Lybrand TP, Breyer RM (2005). "Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.". J. Biol. Chem. 280 (37): 32442–51. doi:10.1074/jbc.M502563200. PMID 16030019.  
  • Sandig H, Andrew D, Barnes AA, et al. (2006). "9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2.". FEBS Lett. 580 (2): 373–9. doi:10.1016/j.febslet.2005.11.052. PMID 16378605.  
  • Schratl P, Royer JF, Kostenis E, et al. (2007). "The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking.". J. Immunol. 179 (7): 4792–9. PMID 17878378.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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