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G protein-coupled receptor 45
Symbols GPR45; PSP24; PSP24(ALPHA); PSP24A
External IDs OMIM604838 MGI2135882 HomoloGene5228 IUPHAR: GPR45 GeneCards: GPR45 Gene
RNA expression pattern
PBB GE GPR45 211175 at tn.png
More reference expression data
Species Human Mouse
Entrez 11250 93690
Ensembl ENSG00000135973 ENSMUSG00000041907
UniProt Q9Y5Y3 Q148B5
RefSeq (mRNA) NM_007227 NM_053107
RefSeq (protein) NP_009158 NP_444337
Location (UCSC) Chr 2:
105.22 - 105.23 Mb
Chr 1:
42.9 - 42.98 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.[1][2]

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.[2]


  1. ^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics 56 (1): 12-21. doi:10.1006/geno.1998.5655. PMID 10036181.  
  2. ^ a b "Entrez Gene: GPR45 G protein-coupled receptor 45".  

Further reading

  • Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.  
  • Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  


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