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G protein-coupled receptor 45
Identifiers
Symbols GPR45; PSP24; PSP24(ALPHA); PSP24A
External IDs OMIM604838 MGI2135882 HomoloGene5228 IUPHAR: GPR45 GeneCards: GPR45 Gene
RNA expression pattern
PBB GE GPR45 211175 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11250 93690
Ensembl ENSG00000135973 ENSMUSG00000041907
UniProt Q9Y5Y3 Q148B5
RefSeq (mRNA) NM_007227 NM_053107
RefSeq (protein) NP_009158 NP_444337
Location (UCSC) Chr 2:
105.22 - 105.23 Mb
Chr 1:
42.9 - 42.98 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.[1][2]

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.[2]

References

  1. ^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics 56 (1): 12-21. doi:10.1006/geno.1998.5655. PMID 10036181.  
  2. ^ a b "Entrez Gene: GPR45 G protein-coupled receptor 45". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11250.  

Further reading

  • Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.  
  • Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
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