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G protein-coupled receptor 56
Symbols GPR56; BFPP; DKFZp781L1398; TM7LN4; TM7XN1
External IDs OMIM604110 MGI1340051 HomoloGene4156 IUPHAR: GPR56 GeneCards: GPR56 Gene
RNA expression pattern
PBB GE GPR56 212070 at tn.png
PBB GE GPR56 206582 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9289 14766
Ensembl ENSG00000205336 ENSMUSG00000031785
UniProt Q9Y653 Q8K209
RefSeq (mRNA) NM_005682 NM_018882
RefSeq (protein) NP_005673 NP_061370
Location (UCSC) Chr 16:
56.24 - 56.26 Mb
Chr 8:
97.87 - 97.9 Mb
PubMed search [1] [2]

G-protein coupled receptor 56 is a protein that in humans is encoded by the GPR56 gene.[1][2][3]

In melanocytic cells GPR56 gene expression may be regulated by MITF[4].


  1. ^ Liu M, Parker RM, Darby K, Eyre HJ, Copeland NG, Crawford J, Gilbert DJ, Sutherland GR, Jenkins NA, Herzog H (May 1999). "GPR56, a novel secretin-like human G-protein-coupled receptor gene". Genomics 55 (3): 296–305. doi:10.1006/geno.1998.5644. PMID 10049584.  
  2. ^ Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN (Apr 1999). "TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential". FEBS Lett 446 (2-3): 292–8. PMID 10100861.  
  3. ^ "Entrez Gene: GPR56 G protein-coupled receptor 56".  
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  

Further reading

  • Xu L, Hynes RO (2007). "GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.". Cell Cycle 6 (2): 160–5. PMID 17314516.  
  • Piao X, Basel-Vanagaite L, Straussberg R, et al. (2002). "An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.". Am. J. Hum. Genet. 70 (4): 1028–33. doi:10.1086/339552. PMID 11845408.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Little KD, Hemler ME, Stipp CS (2005). "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.". Mol. Biol. Cell 15 (5): 2375–87. doi:10.1091/mbc.E03-12-0886. PMID 15004227.  
  • Piao X, Hill RS, Bodell A, et al. (2004). "G protein-coupled receptor-dependent development of human frontal cortex.". Science 303 (5666): 2033–6. doi:10.1126/science.1092780. PMID 15044805.  
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Shashidhar S, Lorente G, Nagavarapu U, et al. (2005). "GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.". Oncogene 24 (10): 1673–82. doi:10.1038/sj.onc.1208395. PMID 15674329.  
  • Sud N, Sharma R, Ray R, et al. (2006). "Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma.". Cancer Lett. 233 (2): 265–70. doi:10.1016/j.canlet.2005.03.018. PMID 15916848.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Xu L, Begum S, Hearn JD, Hynes RO (2006). "GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9023–8. doi:10.1073/pnas.0602681103. PMID 16757564.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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