The Full Wiki

GPR6: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
G protein-coupled receptor 6
Identifiers
Symbols GPR6;
External IDs OMIM600553 MGI2155249 HomoloGene38026 IUPHAR: GPR6 GeneCards: GPR6 Gene
RNA expression pattern
PBB GE GPR6 214655 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2830 140741
Ensembl ENSG00000146360 ENSMUSG00000046922
UniProt P46095 Q2M2N8
RefSeq (mRNA) NM_005284 NM_199058
RefSeq (protein) NP_005275 NP_951013
Location (UCSC) Chr 6:
110.41 - 110.41 Mb
Chr 10:
40.76 - 40.76 Mb
PubMed search [1] [2]

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[1][2]

Contents

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[3]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[4]

See also

References

  1. ^ "Entrez Gene: GPR6 G protein-coupled receptor 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830.  
  2. ^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.  
  3. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.  
  4. ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443.  

Further reading

  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.  
  • Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.". Genomics 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message