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G protein-coupled receptor 63
Symbols GPR63; PSP24(beta); PSP24B
External IDs OMIM606915 MGI2135884 HomoloGene12759 IUPHAR: GPR63 GeneCards: GPR63 Gene
RNA expression pattern
PBB GE GPR63 220993 s at tn.png
More reference expression data
Species Human Mouse
Entrez 81491 81006
Ensembl ENSG00000112218 ENSMUSG00000040372
UniProt Q9BZJ6 Q8BZ93
RefSeq (mRNA) NM_030784 NM_030733
RefSeq (protein) NP_110411 NP_109658
Location (UCSC) Chr 6:
97.35 - 97.39 Mb
Chr 4:
25.06 - 25.1 Mb
PubMed search [1] [2]

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.[1]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][1]


Further reading

  • Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.  
  • Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.  
  • Lee DK, George SR, Cheng R, et al. (2001). "Identification of four novel human G protein-coupled receptors expressed in the brain.". Brain Res. Mol. Brain Res. 86 (1-2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Niedernberg A, Tunaru S, Blaukat A, et al. (2004). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.". Cell. Signal. 15 (4): 435–46. doi:10.1016/S0898-6568(02)00119-5. PMID 12618218.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


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