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G protein-coupled receptor 68
Symbols GPR68; MGC111379; OGR1
External IDs OMIM601404 MGI2441763 HomoloGene2603 IUPHAR: GPR68 GeneCards: GPR68 Gene
RNA expression pattern
PBB GE GPR68 211249 at tn.png
More reference expression data
Species Human Mouse
Entrez 8111 238377
Ensembl ENSG00000119714 ENSMUSG00000047415
UniProt Q15743 Q148P7
RefSeq (mRNA) NM_003485 NM_175493
RefSeq (protein) NP_003476 NP_780702
Location (UCSC) Chr 14:
90.77 - 90.79 Mb
Chr 12:
101.28 - 101.29 Mb
PubMed search [1] [2]

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.[1][2]

See also


  1. ^ Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics 35 (2): 397-402. doi:10.1006/geno.1996.0377. PMID 8661159.  
  2. ^ "Entrez Gene: GPR68 G protein-coupled receptor 68".  

Further reading

  • Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction.". Biochim. Biophys. Acta 1582 (1-3): 81–8. PMID 12069813.  
  • An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.". FEBS Lett. 375 (1-2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Xu Y, Zhu K, Hong G, et al. (2000). "Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.". Nat. Cell Biol. 2 (5): 261–7. doi:10.1038/35010529. PMID 10806476.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors.". Nature 425 (6953): 93–8. doi:10.1038/nature01905. PMID 12955148.  
  • Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.". Biochemistry 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.  
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMID 15665078.  
  • Tomura H, Wang JQ, Komachi M, et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells.". J. Biol. Chem. 280 (41): 34458–64. doi:10.1074/jbc.M505287200. PMID 16087674.  
  • Singh LS, Berk M, Oates R, et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.". J. Natl. Cancer Inst. 99 (17): 1313–27. doi:10.1093/jnci/djm107. PMID 17728215.  


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