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G protein-coupled receptor 77
Identifiers
Symbols GPR77; C5L2; GPF77
External IDs OMIM609949 MGI2442013 HomoloGene49549 IUPHAR: C5L2 GeneCards: GPR77 Gene
RNA expression pattern
PBB GE GPR77 221149 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27202 319430
Ensembl ENSG00000134830 ENSMUSG00000074361
UniProt Q9P296 n/a
RefSeq (mRNA) NM_018485 NM_176912
RefSeq (protein) NP_060955 NP_795886
Location (UCSC) Chr 19:
52.54 - 52.54 Mb
Chr 7:
15.4 - 15.4 Mb
PubMed search [1] [2]

C5a anaphylatoxin chemotactic receptor C5L2 is a protein that in humans is encoded by the GPR77 gene.[1][2]

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005).[supplied by OMIM][2]

References

  1. ^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res 86 (1-2): 13-22. PMID 11165367.  
  2. ^ a b "Entrez Gene: GPR77 G protein-coupled receptor 77". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27202.  

External links

Further reading

  • Ohno M, Hirata T, Enomoto M, et al. (2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.". Mol. Immunol. 37 (8): 407–12. doi:10.1016/S0161-5890(00)00067-5. PMID 11090875.  
  • Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).". J. Biol. Chem. 277 (9): 7165–9. doi:10.1074/jbc.C100714200. PMID 11773063.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kalant D, Cain SA, Maslowska M, et al. (2003). "The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.". J. Biol. Chem. 278 (13): 11123–9. doi:10.1074/jbc.M206169200. PMID 12540846.  
  • Otto M, Hawlisch H, Monk PN, et al. (2004). "C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.". J. Biol. Chem. 279 (1): 142–51. doi:10.1074/jbc.M310078200. PMID 14570896.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Huber-Lang M, Sarma JV, Rittirsch D, et al. (2005). "Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.". J. Immunol. 174 (2): 1104–10. PMID 15634936.  
  • Kalant D, MacLaren R, Cui W, et al. (2005). "C5L2 is a functional receptor for acylation-stimulating protein.". J. Biol. Chem. 280 (25): 23936–44. doi:10.1074/jbc.M406921200. PMID 15833747.  
  • Johswich K, Martin M, Thalmann J, et al. (2007). "Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.". J. Biol. Chem. 281 (51): 39088–95. doi:10.1074/jbc.M609734200. PMID 17068344.  
  • Scola AM, Higginbottom A, Partridge LJ, et al. (2007). "The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.". J. Biol. Chem. 282 (6): 3664–71. doi:10.1074/jbc.M609178200. PMID 17158873.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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