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G protein-coupled receptor, family C, group 5, member A
External IDs OMIM604138 MGI1891250 HomoloGene2961 IUPHAR: RAIG1 GeneCards: GPRC5A Gene
Species Human Mouse
Entrez 9052 232431
Ensembl ENSG00000013588 ENSMUSG00000046733
UniProt Q8NFJ5 Q8BHL4
RefSeq (mRNA) NM_003979 NM_181444
RefSeq (protein) NP_003970 NP_852109
Location (UCSC) Chr 12:
12.93 - 12.96 Mb
Chr 6:
135.03 - 135.05 Mb
PubMed search [1] [2]

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[1][2]

This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[2]


See also


  1. ^ Cheng Y, Lotan R (Feb 1999). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J Biol Chem 273 (52): 35008-15. PMID 9857033.  
  2. ^ a b "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".  

External links

Further reading

  • Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1997). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells.". Cell. Mol. Biol. (Noisy-le-grand) 42 (5): 797–804. PMID 8832110.  
  • Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain.". Genomics 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.  
  • Robbins MJ, Michalovich D, Hill J, et al. (2001). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).". Genomics 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid.". Genomics 83 (2): 270–80. doi:10.1016/S0888-7543(03)00237-4. PMID 14706456.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wu Q, Ding W, Mirza A, et al. (2005). "Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target.". J. Biol. Chem. 280 (13): 12935–43. doi:10.1074/jbc.M409901200. PMID 15659406.  
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.  
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.  
  • Hirano M, Zang L, Oka T, et al. (2006). "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression.". Biochem. Biophys. Res. Commun. 351 (1): 185–91. doi:10.1016/j.bbrc.2006.10.016. PMID 17055459.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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