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G protein-coupled receptor, family C, group 6, member A
Identifiers
Symbols GPRC6A; GPCR; bA86F4.3
External IDs MGI2429498 HomoloGene17529 IUPHAR: GPRC6 GeneCards: GPRC6A Gene
Orthologs
Species Human Mouse
Entrez 222545 210198
Ensembl ENSG00000173612 ENSMUSG00000019905
UniProt Q5T6X5 Q8K4Z6
RefSeq (mRNA) NM_148963 NM_153071
RefSeq (protein) NP_683766 NP_694711
Location (UCSC) Chr 6:
117.22 - 117.26 Mb
Chr 10:
51.3 - 51.32 Mb
PubMed search [1] [2]

G-protein coupled receptor family C group 6 member A is a protein that in humans is encoded by the GPRC6A gene.[1] This receptor functions as a sensor of L-amino acids.[2]

References

  1. ^ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=222545.  
  2. ^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.  

Further reading

  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.  
  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.". Gene 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.  
  • Wellendorph P, Hansen KB, Balsgaard A, et al. (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.  
  • Pi M, Faber P, Ekema G, et al. (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor.". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMID 16199532.  

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