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Glutamate receptor, ionotropic, kainate 1

PDB rendering based on 1txf.
Available structures
1txf, 1ycj, 2f34, 2f35, 2f36, 2ojt
Symbols GRIK1; EAA3; EEA3; GLR5; GLUR5
External IDs OMIM138245 MGI95814 HomoloGene68992 GeneCards: GRIK1 Gene
RNA expression pattern
PBB GE GRIK1 207242 s at tn.png
PBB GE GRIK1 214611 at tn.png
More reference expression data
Species Human Mouse
Entrez 2897 14805
Ensembl ENSG00000171189 ENSMUSG00000022935
UniProt P39086 n/a
RefSeq (mRNA) NM_000830 NM_010348
RefSeq (protein) NP_000821 NP_034478
Location (UCSC) Chr 21:
29.83 - 30.23 Mb
Chr 16:
87.79 - 88.18 Mb
PubMed search [1] [2]

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein which in humans is encoded by the GRIK1 gene.[1]



This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as a ligand-gated ion channel. The specific GluR subunit encoded by this gene is of the kainate receptor subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. Two alternatively spliced transcript variants that encode different isoforms have been described. Exons of this gene are interspersed with exons from the C21orf41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein.[1]


GRIK1 has been shown to interact with DLG4,[2] PICK1[2] and SDCBP.[2]

See also


  1. ^ a b "Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1".  
  2. ^ a b c Hirbec, Hélène; Francis Joanna C, Lauri Sari E, Braithwaite Steven P, Coussen Françoise, Mulle Christophe, Dev Kumlesh K, Coutinho Victoria, Meyer Guido, Isaac John T R, Collingridge Graham L, Henley Jeremy M, Couthino Victoria (Feb. 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron (United States) 37 (4): 625–38. ISSN 0896-6273. PMID 12597860.  

Further reading

  • Nutt SL, Kamboj RK (1995). "RNA editing of human kainate receptor subunits.". Neuroreport 5 (18): 2625–9. PMID 7696618.  
  • Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.  
  • Gregor P, O'Hara BF, Yang X, Uhl GR (1994). "Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.". Neuroreport 4 (12): 1343–6. PMID 8260617.  
  • Eubanks JH, Puranam RS, Kleckner NW, et al. (1993). "The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 178–82. doi:10.1073/pnas.90.1.178. PMID 8419920.  
  • Potier MC, Dutriaux A, Lambolez B, et al. (1993). "Assignment of the human glutamate receptor gene GLUR5 to 21q22 by screening a chromosome 21 YAC library.". Genomics 15 (3): 696–7. doi:10.1006/geno.1993.1131. PMID 8468067.  
  • Korczak B, Nutt SL, Fletcher EJ, et al. (1996). "cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration.". Recept. Channels 3 (1): 41–9. PMID 8589992.  
  • Brakeman PR, Lanahan AA, O'Brien R, et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors.". Nature 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.  
  • Sander T, Hildmann T, Kretz R, et al. (1997). "Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism.". Am. J. Med. Genet. 74 (4): 416–21. doi:10.1002/(SICI)1096-8628(19970725)74:4<416::AID-AJMG13>3.0.CO;2-L. PMID 9259378.  
  • Clarke VR, Ballyk BA, Hoo KH, et al. (1997). "A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission.". Nature 389 (6651): 599–603. doi:10.1038/39315. PMID 9335499.  
  • Xiao B, Tu JC, Petralia RS, et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.". Neuron 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.  
  • Montague AA, Greer CA (1999). "Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb.". J. Comp. Neurol. 405 (2): 233–46. doi:10.1002/(SICI)1096-9861(19990308)405:2<233::AID-CNE7>3.0.CO;2-A. PMID 10023812.  
  • Bortolotto ZA, Clarke VR, Delany CM, et al. (1999). "Kainate receptors are involved in synaptic plasticity.". Nature 402 (6759): 297–301. doi:10.1038/46290. PMID 10580501.  
  • Barbon A, Barlati S (2000). "Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1.". Cytogenet. Cell Genet. 88 (3-4): 236–9. doi:10.1159/000015558. PMID 10828597.  
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.  
  • Ango F, Prézeau L, Muller T, et al. (2001). "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.". Nature 411 (6840): 962–5. doi:10.1038/35082096. PMID 11418862.  
  • Shibata H, Joo A, Fujii Y, et al. (2002). "Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia.". Psychiatr. Genet. 11 (3): 139–44. doi:10.1097/00041444-200109000-00005. PMID 11702055.  
  • Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.  
  • Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.". FEBS Lett. 514 (2-3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148.  
  • Hirbec H, Francis JC, Lauri SE, et al. (2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.". Neuron 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. PMID 12597860.  
  • Ren Z, Riley NJ, Needleman LA, et al. (2004). "Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal.". J. Biol. Chem. 278 (52): 52700–9. doi:10.1074/jbc.M309585200. PMID 14527949.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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