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Glutamate receptor, ionotropic, kainate 3
Symbols GRIK3; EAA5; GLR7; GLUR7; GluR7a
External IDs OMIM138243 MGI95816 HomoloGene73901 GeneCards: GRIK3 Gene
RNA expression pattern
PBB GE GRIK3 207454 at tn.png
More reference expression data
Species Human Mouse
Entrez 2899 14807
Ensembl ENSG00000163873 ENSMUSG00000001985
UniProt Q13003 n/a
RefSeq (mRNA) NM_000831 XM_131647
RefSeq (protein) NP_000822 XP_131647
Location (UCSC) Chr 1:
37.03 - 37.27 Mb
Chr 4:
125.13 - 125.21 Mb
PubMed search [1] [2]

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.[1][2]

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.[2]



GRIK3 has been shown to interact with GRIP1[3] and PICK1.[3]

See also


  1. ^ Puranam RS, Eubanks JH, Heinemann SF, McNamara JO (Apr 1994). "Chromosomal localization of gene for human glutamate receptor subunit-7". Somat Cell Mol Genet 19 (6): 581–8. PMID 8128318.  
  2. ^ a b "Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3".  
  3. ^ a b Hirbec, Hélène; Perestenko Olga, Nishimune Atsushi, Meyer Guido, Nakanishi Shigetada, Henley Jeremy M, Dev Kumlesh K (May. 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. (United States) 277 (18): 15221–4. doi:10.1074/jbc.C200112200. ISSN 0021-9258. PMID 11891216.  

Further reading

  • Nutt SL, Hoo KH, Rampersad V, et al. (1995). "Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites.". Recept. Channels 2 (4): 315–26. PMID 7719709.  
  • Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.  
  • Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Schiffer HH, Swanson GT, Masliah E, Heinemann SF (2001). "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.". J. Neurosci. 20 (24): 9025–33. PMID 11124978.  
  • Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.". FEBS Lett. 514 (2-3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148.  
  • Begni S, Popoli M, Moraschi S, et al. (2002). "Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.". Mol. Psychiatry 7 (4): 416–8. doi:10.1038/ PMID 11986986.  
  • Delorme R, Krebs MO, Chabane N, et al. (2004). "Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.". Neuroreport 15 (4): 699–702. doi:10.1097/00001756-200403220-00025. PMID 15094479.  
  • Preuss UW, Zill P, Koller G, et al. (2006). "Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics.". Pharmacogenomics J. 6 (1): 34–41. doi:10.1038/sj.tpj.6500343. PMID 16314883.  
  • Samochowiec J, Grzywacz A, Kucharska-Mazur J, et al. (2006). "Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence.". Neurosci. Lett. 396 (2): 159–62. doi:10.1016/j.neulet.2005.11.030. PMID 16356644.  
  • Schiffer HH, Heinemann SF (2007). "Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (1): 20–6. doi:10.1002/ajmg.b.30374. PMID 16958029.  
  • Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags.". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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