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Glutamate receptor, ionotropic, kainate 5
Symbols GRIK5; GRIK2; EAA2; KA2
External IDs OMIM600283 MGI95818 HomoloGene1578 GeneCards: GRIK5 Gene
RNA expression pattern
PBB GE GRIK5 214966 at tn.png
PBB GE GRIK5 217509 x at tn.png
More reference expression data
Species Human Mouse
Entrez 2901 14809
Ensembl ENSG00000105737 ENSMUSG00000003378
UniProt Q16478 Q2TAX1
RefSeq (mRNA) NM_002088 XM_989663
RefSeq (protein) NP_002079 XP_994757
Location (UCSC) Chr 19:
47.19 - 47.26 Mb
Chr 7:
24.72 - 24.78 Mb
PubMed search [1] [2]

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1][2]

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2]



GRIK5 has been shown to interact with DLG4[3][4] and GRIK2.[5][6]

See also


  1. ^ Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG, et al. (Jan 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A 91 (25): 11849–53. PMID 7527545.  
  2. ^ a b "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5".  
  3. ^ Mehta, S; Wu H, Garner C C, Marshall J (May. 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. (United States) 276 (19): 16092–9. doi:10.1074/jbc.M100643200. ISSN 0021-9258. PMID 11279111.  
  4. ^ Garcia, E P; Mehta S, Blair L A, Wells D G, Shang J, Fukushima T, Fallon J R, Garner C C, Marshall J (Oct. 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron (UNITED STATES) 21 (4): 727–39. ISSN 0896-6273. PMID 9808460.  
  5. ^ Wenthold, R J; Trumpy V A, Zhu W S, Petralia R S (Jan. 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. (UNITED STATES) 269 (2): 1332–9. ISSN 0021-9258. PMID 8288598.  
  6. ^ Ripellino, J A; Neve R L, Howe J R (Jan. 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience (UNITED STATES) 82 (2): 485–97. ISSN 0306-4522. PMID 9466455.  

Further reading

  • Kamboj RK, Schoepp DD, Nutt S, et al. (1992). "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.". Mol. Pharmacol. 42 (1): 10–5. PMID 1321949.  
  • Cauley K, Kukekov V, Young D (1997). "Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture.". J. Neurosci. Res. 47 (3): 311–21. doi:10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L. PMID 9039653.  
  • Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.". Brain Res. 751 (2): 217–31. doi:10.1016/S0006-8993(96)01404-7. PMID 9099808.  
  • Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.  
  • Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460.  
  • Mehta S, Wu H, Garner CC, Marshall J (2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kohda K, Kamiya Y, Matsuda S, et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.". Brain Res. Mol. Brain Res. 110 (1): 27–37. doi:10.1016/S0169-328X(02)00561-2. PMID 12573530.  
  • Hayes DM, Braud S, Hurtado DE, et al. (2003). "Trafficking and surface expression of the glutamate receptor subunit, KA2.". Biochem. Biophys. Res. Commun. 310 (1): 8–13. doi:10.1016/j.bbrc.2003.08.115. PMID 14511640.  
  • Kamm C, Leung J, Joseph S, et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene.". Mov. Disord. 19 (7): 845–7. doi:10.1002/mds.20095. PMID 15254951.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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