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Glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Identifiers
Symbols GRIN2B; MGC142178; MGC142180; NMDAR2B; NR2B; hNR3
External IDs OMIM138252 MGI95821 HomoloGene646 GeneCards: GRIN2B Gene
RNA expression pattern
PBB GE GRIN2B 210412 at tn.png
PBB GE GRIN2B 210411 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2904 14812
Ensembl ENSG00000150086 ENSMUSG00000030209
UniProt Q13224 Q8CG69
RefSeq (mRNA) NM_000834 NM_008171
RefSeq (protein) NP_000825 NP_032197
Location (UCSC) Chr 12:
13.61 - 14.02 Mb
Chr 6:
135.7 - 136.01 Mb
PubMed search [1] [2]

Glutamate [NMDA] receptor subunit epsilon-2 is a protein that in humans is encoded by the GRIN2B gene.[1]

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentatorubral-pallidoluysian atrophy (DRPLA)[2]

Contents

Interactions

GRIN2B has been shown to interact with LIN7B,[3] DLG4,[4][5][6][7][8][9] DLG2,[5][6] DLG3,[4][5][6][8] EXOC4,[4] RICS[10] and Actinin, alpha 2.[11]

See also

References

  1. ^ Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science 256 (5060): 1217–21. PMID 1350383.  
  2. ^ "Entrez Gene: GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2904.  
  3. ^ Jo, K; Derin R, Li M, Bredt D S (Jun. 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J. Neurosci. (UNITED STATES) 19 (11): 4189–99. PMID 10341223.  
  4. ^ a b c Sans, Nathalie; Prybylowski Kate, Petralia Ronald S, Chang Kai, Wang Ya-Xian, Racca Claudia, Vicini Stefano, Wenthold Robert J (Jun. 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. (England) 5 (6): 520–30. doi:10.1038/ncb990. ISSN 1465-7392. PMID 12776120.  
  5. ^ a b c Inanobe, Atsushi; Fujita Akikazu, Ito Minoru, Tomoike Hitonobu, Inageda Kiyoshi, Kurachi Yoshihisa (Jun. 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. (United States) 282 (6): C1396-403. doi:10.1152/ajpcell.00615.2001. ISSN 0363-6143. PMID 11997254.  
  6. ^ a b c Irie, M; Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl T W, Südhof T C (Sep. 1997). "Binding of neuroligins to PSD-95". Science (UNITED STATES) 277 (5331): 1511–5. ISSN 0036-8075. PMID 9278515.  
  7. ^ Niethammer, M; Valtschanoff J G, Kapoor T M, Allison D W, Weinberg R J, Craig A M, Sheng M (Apr. 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron (UNITED STATES) 20 (4): 693–707. ISSN 0896-6273. PMID 9581762.  
  8. ^ a b Lim, Indra Adi; Hall Duane D, Hell Johannes W (Jun. 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. (United States) 277 (24): 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.  
  9. ^ Kornau, H C; Schenker L T, Kennedy M B, Seeburg P H (Sep. 1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science (UNITED STATES) 269 (5231): 1737–40. ISSN 0036-8075. PMID 7569905.  
  10. ^ Nakazawa, Takanobu; Watabe Ayako M, Tezuka Tohru, Yoshida Yutaka, Yokoyama Kazumasa, Umemori Hisashi, Inoue Akihiro, Okabe Shigeo, Manabe Toshiya, Yamamoto Tadashi (Jul. 2003). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling". Mol. Biol. Cell (United States) 14 (7): 2921–34. doi:10.1091/mbc.E02-09-0623. ISSN 1059-1524. PMID 12857875.  
  11. ^ Wyszynski, M; Lin J, Rao A, Nigh E, Beggs A H, Craig A M, Sheng M (Jan. 1997). "Competitive binding of alpha-actinin and calmodulin to the NMDA receptor". Nature (ENGLAND) 385 (6615): 439–42. doi:10.1038/385439a0. ISSN 0028-0836. PMID 9009191.  

Further reading

  • Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683–8. PMID 9745929.  
  • Nagy J (2004). "The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence.". Current drug targets. CNS and neurological disorders 3 (3): 169–79. doi:10.2174/1568007043337409. PMID 15180478.  
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity.". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.  
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.". Science 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905.  
  • Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.  
  • Mandich P, Schito AM, Bellone E, et al. (1994). "Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.". Genomics 22 (1): 216–8. doi:10.1006/geno.1994.1366. PMID 7959773.  
  • Adams SL, Foldes RL, Kamboj RK (1995). "Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein.". Biochim. Biophys. Acta 1260 (1): 105–8. PMID 7999784.  
  • Sheng M, Cummings J, Roldan LA, et al. (1994). "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.". Nature 368 (6467): 144–7. doi:10.1038/368144a0. PMID 8139656.  
  • Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.  
  • Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.  
  • Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 4 (3): 315–21. PMID 8581564.  
  • Niethammer M, Kim E, Sheng M (1996). "Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.". J. Neurosci. 16 (7): 2157–63. PMID 8601796.  
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.". AIDS 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036.  
  • Hess SD, Daggett LP, Crona J, et al. (1996). "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.". J. Pharmacol. Exp. Ther. 278 (2): 808–16. PMID 8768735.  
  • Müller BM, Kistner U, Kindler S, et al. (1996). "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.". Neuron 17 (2): 255–65. doi:10.1016/S0896-6273(00)80157-9. PMID 8780649.  
  • Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.". Neuroreport 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048.  
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.". Brain Res. 705 (1-2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747.  
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372.  
  • Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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