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Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Symbols GRIN3A; FLJ45414; NMDAR-L; NR3A
External IDs OMIM606650 HomoloGene15851 GeneCards: GRIN3A Gene
RNA expression pattern
PBB GE GRIN3A gnf1h05166 at tn.png
PBB GE GRIN3A gnf1h08344 at tn.png
More reference expression data
Species Human Mouse
Entrez 116443 n/a
Ensembl ENSG00000198785 n/a
UniProt Q8TCU5 n/a
RefSeq (mRNA) NM_133445 n/a
RefSeq (protein) NP_597702 n/a
Location (UCSC) Chr 9:
103.37 - 103.54 Mb
PubMed search [1] n/a

Glutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene.[1]

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.[1]


See also


Further reading

  • Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683–8. PMID 9745929.  
  • Eriksson M, Nilsson A, Samuelsson H, et al. (2007). "On the role of NR3A in human NMDA receptors.". Physiol. Behav. 92 (1-2): 54–9. doi:10.1016/j.physbeh.2007.05.026. PMID 17617428.  
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.". Science 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905.  
  • Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.  
  • Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.  
  • Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 4 (3): 315–21. PMID 8581564.  
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.". AIDS 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036.  
  • Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.". Neuroreport 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048.  
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.". Brain Res. 705 (1-2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747.  
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372.  
  • Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955.  
  • Raber J, Toggas SM, Lee S, et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.". Virology 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.  
  • Das S, Sasaki YF, Rothe T, et al. (1998). "Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A.". Nature 393 (6683): 377–81. doi:10.1038/30748. PMID 9620802.  
  • New DR, Maggirwar SB, Epstein LG, et al. (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.". J. Biol. Chem. 273 (28): 17852–8. doi:10.1074/jbc.273.28.17852. PMID 9651389.  
  • Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats.". Neuroscience 88 (2): 585–97. doi:10.1016/S0306-4522(98)00242-5. PMID 10197777.  
  • Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.". Exp. Neurol. 158 (1): 164–70. doi:10.1006/exnr.1999.7080. PMID 10448428.  
  • Xin KQ, Hamajima K, Hattori S, et al. (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.". AIDS Res. Hum. Retroviruses 15 (16): 1461–7. doi:10.1089/088922299309973. PMID 10555109.  
  • Perez-Otano I, Schulteis CT, Contractor A, et al. (2001). "Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors.". J. Neurosci. 21 (4): 1228–37. PMID 11160393.  
  • Haughey NJ, Nath A, Mattson MP, et al. (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity.". J. Neurochem. 78 (3): 457–67. doi:10.1046/j.1471-4159.2001.00396.x. PMID 11483648.  

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