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Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
Identifiers
Symbols GRIN3B; NR3B
External IDs OMIM: 606651 MGI: 2150393 HomoloGene: 15606 GeneCards: GRIN3B Gene
Orthologs
Species Human Mouse
Entrez 116444 170483
Ensembl ENSG00000116032 ENSMUSG00000035745
UniProt O60391 Q91ZU9
RefSeq (mRNA) NM_138690 NM_130455
RefSeq (protein) NP_619635 NP_569722
Location (UCSC) Chr 19:
0.95 - 0.96 Mb		 Chr 10:
79.37 - 79.38 Mb
PubMed search [1] [2]

Glutamate [NMDA] receptor subunit 3B is a protein that in humans is encoded by the GRIN3B gene.[1]

Contents

See also

References

  1. ^ "Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116444.  

Further reading

  • Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology 19 (4-5): 683–8. PMID 9745929.  
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.". Science 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905.  
  • Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.  
  • Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.  
  • Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 4 (3): 315–21. PMID 8581564.  
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.". AIDS 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036.  
  • Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.". Neuroreport 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048.  
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.". Brain Res. 705 (1-2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747.  
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372.  
  • Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Raber J, Toggas SM, Lee S, et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.". Virology 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.  
  • New DR, Maggirwar SB, Epstein LG, et al. (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.". J. Biol. Chem. 273 (28): 17852–8. doi:10.1074/jbc.273.28.17852. PMID 9651389.  
  • Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats.". Neuroscience 88 (2): 585–97. doi:10.1016/S0306-4522(98)00242-5. PMID 10197777.  
  • Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.". Exp. Neurol. 158 (1): 164–70. doi:10.1006/exnr.1999.7080. PMID 10448428.  
  • Xin KQ, Hamajima K, Hattori S, et al. (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.". AIDS Res. Hum. Retroviruses 15 (16): 1461–7. doi:10.1089/088922299309973. PMID 10555109.  
  • Haughey NJ, Nath A, Mattson MP, et al. (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity.". J. Neurochem. 78 (3): 457–67. doi:10.1046/j.1471-4159.2001.00396.x. PMID 11483648.  
  • Bonavia R, Bajetto A, Barbero S, et al. (2001). "HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.". Biochem. Biophys. Res. Commun. 288 (2): 301–8. doi:10.1006/bbrc.2001.5743. PMID 11606043.  
  • Nishi M, Hinds H, Lu HP, et al. (2002). "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner.". J. Neurosci. 21 (23): RC185. PMID 11717388.  

External links

Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABAA (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ (ρ1, ρ2, ρ3)
α1 · α2 · α3 · α4 · β
monomers: α1 · α2 · α3 · α4 · α5 · α6 · α7 · α9 · α10 · β1 · β2 · β3 · β4 · δ · ε
pentamers: (α3)2(β4)3 · (α4)2(β2)3 · (α7)5 · (α1)2(β4)3 - Ganglion type · (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated
NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
ATP-gated channels
P2X (1, 2, 3, 4, 5, 6, 7)







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