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From Wikipedia, the free encyclopedia

Glucocorticoid receptor DNA binding factor 1
Symbols GRLF1; GRF-1; KIAA1722; MGC10745; P190-A; P190A; p190RhoGAP
External IDs OMIM605277 MGI1929494 HomoloGene35136 GeneCards: GRLF1 Gene
RNA expression pattern
PBB GE GRLF1 202046 s at tn.png
PBB GE GRLF1 202044 at tn.png
PBB GE GRLF1 gnf1h03426 at tn.png
More reference expression data
Species Human Mouse
Entrez 2909 232906
Ensembl ENSG00000160007 ENSMUSG00000058230
UniProt Q9NRY4 Q3TSU7
RefSeq (mRNA) NM_004491 NM_172739
RefSeq (protein) NP_004482 NP_766327
Location (UCSC) Chr 19:
52.11 - 52.2 Mb
Chr 7:
15.65 - 15.77 Mb
PubMed search [1] [2]

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.[1][2]

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.[2]


  1. ^ LeClerc S, Palaniswami R, Xie BX, Govindan MV (Oct 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". J Biol Chem 266 (26): 17333-40. PMID 1894621.  
  2. ^ a b "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1".  

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.  
  • Warriar N, Pagé N, Govindan MV (1996). "Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element.". J. Biol. Chem. 271 (31): 18662–71. doi:10.1074/jbc.271.31.18662. PMID 8702520.  
  • Tikoo A, Czekay S, Viars C, et al. (2001). "p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.". Gene 257 (1): 23–31. doi:10.1016/S0378-1119(00)00387-5. PMID 11054565.  
  • Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.  
  • Barberis D, Casazza A, Sordella R, et al. (2006). "p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.". J. Cell. Sci. 118 (Pt 20): 4689–700. doi:10.1242/jcs.02590. PMID 16188938.  
  • Holinstat M, Knezevic N, Broman M, et al. (2006). "Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.". J. Biol. Chem. 281 (4): 2296–305. doi:10.1074/jbc.M511248200. PMID 16308318.  
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Mammoto T, Parikh SM, Mammoto A, et al. (2007). "Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.". J. Biol. Chem. 282 (33): 23910–8. doi:10.1074/jbc.M702169200. PMID 17562701.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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