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General transcription factor IIF, polypeptide 1, 74kDa

PDB rendering based on 1f3u.
Available structures
1f3u, 1i27, 1j2x, 1nha, 1onv
Identifiers
Symbols GTF2F1; BTF4; RAP74; TF2F1; TFIIF
External IDs OMIM189968 MGI1923848 HomoloGene1585 GeneCards: GTF2F1 Gene
Orthologs
Species Human Mouse
Entrez 2962 98053
Ensembl ENSG00000125651 ENSMUSG00000002658
UniProt P35269 Q8R5B7
RefSeq (mRNA) NM_002096 NM_133801
RefSeq (protein) NP_002087 NP_598562
Location (UCSC) Chr 19:
6.24 - 6.34 Mb
Chr 17:
56.69 - 56.7 Mb
PubMed search [1] [2]

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.[1][2]

Contents

Interactions

GTF2F1 has been shown to interact with TAF1,[3][4][5][6] HNRPU,[7] GTF2H4,[8] CTDP1,[9] TATA binding protein,[8][4][6] POLR2A,[8][10] MED21,[8][11] TAF11,[8] Serum response factor[12][13] and Transcription Factor II B.[8][14]

See also

References

  1. ^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (Mar 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature 355 (6359): 464–7. doi:10.1038/355464a0. PMID 1734284.  
  2. ^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2962.  
  3. ^ Dikstein, R; Ruppert S, Tjian R (Mar. 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell (UNITED STATES) 84 (5): 781–90. ISSN 0092-8674. PMID 8625415.  
  4. ^ a b Ruppert, S; Tjian R (Nov. 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. (UNITED STATES) 9 (22): 2747–55. ISSN 0890-9369. PMID 7590250.  
  5. ^ Siegert, J L; Robbins P D (Jan. 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. (UNITED STATES) 19 (1): 846–54. ISSN 0270-7306. PMID 9858607.  
  6. ^ a b Malik, S; Guermah M, Roeder R G (Mar. 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (5): 2192–7. ISSN 0027-8424. PMID 9482861.  
  7. ^ Kim, M K; Nikodem V M (Oct. 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6833–44. ISSN 0270-7306. PMID 10490622.  
  8. ^ a b c d e f Scully, R; Anderson S F, Chao D M, Wei W, Ye L, Young R A, Livingston D M, Parvin J D (May. 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. ISSN 0027-8424. PMID 9159119.  
  9. ^ Archambault, J; Pan G, Dahmus G K, Cartier M, Marshall N, Zhang S, Dahmus M E, Greenblatt J (Oct. 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. (UNITED STATES) 273 (42): 27593–601. ISSN 0021-9258. PMID 9765293.  
  10. ^ Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63. ISSN 0270-7306. PMID 9710619.  
  11. ^ Suñé, C; Hayashi T, Liu Y, Lane W S, Young R A, Garcia-Blanco M A (Oct. 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. (UNITED STATES) 17 (10): 6029–39. ISSN 0270-7306. PMID 9315662.  
  12. ^ Joliot, V; Demma M, Prywes R (Feb. 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature (ENGLAND) 373 (6515): 632–5. doi:10.1038/373632a0. ISSN 0028-0836. PMID 7854423.  
  13. ^ Zhu, H; Joliot V, Prywes R (Feb. 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. (UNITED STATES) 269 (5): 3489–97. ISSN 0021-9258. PMID 8106390.  
  14. ^ Fang, S M; Burton Z F (May. 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. (UNITED STATES) 271 (20): 11703–9. ISSN 0021-9258. PMID 8662660.  

Further reading

  • Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.  
  • Aso T, Vasavada HA, Kawaguchi T, et al. (1992). "Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF.". Nature 355 (6359): 461–4. doi:10.1038/355461a0. PMID 1734283.  
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. doi:10.1038/377003b0. PMID 7566098.  
  • Ruppert S, Tjian R (1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.". Genes Dev. 9 (22): 2747–55. doi:10.1101/gad.9.22.2747. PMID 7590250.  
  • Hisatake K, Ohta T, Takada R, et al. (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195–9. doi:10.1073/pnas.92.18.8195. PMID 7667268.  
  • Joliot V, Demma M, Prywes R (1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor.". Nature 373 (6515): 632–5. doi:10.1038/373632a0. PMID 7854423.  
  • Zhu H, Joliot V, Prywes R (1994). "Role of transcription factor TFIIF in serum response factor-activated transcription.". J. Biol. Chem. 269 (5): 3489–97. PMID 8106390.  
  • Yonaha M, Aso T, Kobayashi Y, et al. (1993). "Domain structure of a human general transcription initiation factor, TFIIF.". Nucleic Acids Res. 21 (2): 273–9. doi:10.1093/nar/21.2.273. PMID 8441635.  
  • Aso T, Tsai P, Kawaguchi T, et al. (1993). "Assignment of the human GTF2F1 gene to chromosome 19p13.3.". Genomics 16 (1): 252–3. doi:10.1006/geno.1993.1168. PMID 8486367.  
  • Dikstein R, Ruppert S, Tjian R (1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74.". Cell 84 (5): 781–90. doi:10.1016/S0092-8674(00)81055-7. PMID 8625415.  
  • Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703. PMID 8662660.  
  • McEwan IJ, Dahlman-Wright K, Ford J, Wright AP (1996). "Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding.". Biochemistry 35 (29): 9584–93. doi:10.1021/bi960793v. PMID 8755740.  
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451.  
  • Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.". Nature 384 (6607): 375–8. doi:10.1038/384375a0. PMID 8934526.  
  • Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.  
  • Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMID 9159119.  
  • McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8485–90. doi:10.1073/pnas.94.16.8485. PMID 9238003.  
  • Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression.". Biochemistry 36 (34): 10451–62. doi:10.1021/bi971008x. PMID 9265625.  
  • O'Brien T, Tjian R (1998). "Functional analysis of the human TAFII250 N-terminal kinase domain.". Mol. Cell 1 (6): 905–11. doi:10.1016/S1097-2765(00)80089-1. PMID 9660973.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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