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GTF3C1: Wikis


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General transcription factor IIIC, polypeptide 1, alpha 220kDa
Symbols GTF3C1; DKFZp686A111; TFIIIC; TFIIIC220; TFIIICalpha
External IDs OMIM603246 MGI107887 HomoloGene31040 GeneCards: GTF3C1 Gene
RNA expression pattern
PBB GE GTF3C1 35671 at tn.png
PBB GE GTF3C1 202320 at tn.png
More reference expression data
Species Human Mouse
Entrez 2975 233863
Ensembl ENSG00000077235 ENSMUSG00000032777
UniProt Q12789 A0JLN7
RefSeq (mRNA) NM_001520 NM_207239
RefSeq (protein) NP_001511 NP_997122
Location (UCSC) Chr 16:
27.38 - 27.47 Mb
Chr 7:
125.43 - 125.5 Mb
PubMed search [1] [2]

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.[1][2][3]



GTF3C1 has been shown to interact with GTF3C4.[4]


  1. ^ Lagna G, Kovelman R, Sukegawa J, Roeder RG (May 1994). "Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC". Mol Cell Biol 14 (5): 3053–64. PMID 8164661.  
  2. ^ L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ (Apr 1994). "Human transcription factor IIIC box B binding subunit". Proc Natl Acad Sci U S A 91 (5): 1652–6. PMID 8127861.  
  3. ^ "Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa".  
  4. ^ Hsieh, Y J; Kundu T K, Wang Z, Kovelman R, Roeder R G (Nov. 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7697–704. ISSN 0270-7306. PMID 10523658.  

Further reading

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.  
  • Kovelman R, Roeder RG (1992). "Purification and characterization of two forms of human transcription factor IIIC.". J. Biol. Chem. 267 (34): 24446–56. PMID 1447193.  
  • Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III.". Mol. Cell 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.  
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.  
  • Hsieh YJ, Kundu TK, Wang Z, et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.". Mol. Cell. Biol. 19 (11): 7697–704. PMID 10523658.  
  • Meissner W, Thomae R, Seifart KH (2002). "The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.". J. Biol. Chem. 277 (9): 7148–56. doi:10.1074/jbc.M108721200. PMID 11741993.  
  • Zhan Y, Hegde R, Srinivasula SM, et al. (2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.". Cell Death Differ. 9 (4): 439–47. doi:10.1038/sj/cdd/4401038. PMID 11965497.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Weser S, Riemann J, Seifart KH, Meissner W (2003). "Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene.". Nucleic Acids Res. 31 (9): 2408–16. doi:10.1093/nar/gkg345. PMID 12711686.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Dumay-Odelot H, Marck C, Durrieu-Gaillard S, et al. (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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