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Galanin receptor 1
Identifiers
Symbols GALR1; GALNR; GALNR1
External IDs OMIM600377 MGI1096364 HomoloGene74396 IUPHAR: GAL1 GeneCards: GALR1 Gene
RNA expression pattern
PBB GE GALR1 220821 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2587 14427
Ensembl ENSG00000166573 ENSMUSG00000024553
UniProt P47211 P56479
RefSeq (mRNA) NM_001480 NM_008082
RefSeq (protein) NP_001471 NP_032108
Location (UCSC) Chr 18:
73.09 - 73.11 Mb
Chr 18:
82.53 - 82.54 Mb
PubMed search [1] [2]

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[1]

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[1]

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Further reading

  • Habert-Ortoli E, Amiranoff B, Loquet I, et al. (1994). "Molecular cloning of a functional human galanin receptor.". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9780–3. doi:10.1073/pnas.91.21.9780. PMID 7524088.  
  • Walli R, Schäfer H, Morys-Wortmann C, et al. (1995). "Identification and biochemical characterization of the human brain galanin receptor.". J. Mol. Endocrinol. 13 (3): 347–56. doi:10.1677/jme.0.0130347. PMID 7534460.  
  • Kask K, Berthold M, Kahl U, et al. (1996). "Delineation of the peptide binding site of the human galanin receptor.". Embo J. 15 (2): 236–44. PMID 8617199.  
  • Lorimer DD, Benya RV (1996). "Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract.". Biochem. Biophys. Res. Commun. 222 (2): 379–85. doi:10.1006/bbrc.1996.0752. PMID 8670213.  
  • Nicholl J, Kofler B, Sutherland GR, et al. (1997). "Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization.". Genomics 30 (3): 629–30. doi:10.1006/geno.1995.1292. PMID 8825658.  
  • Sullivan KA, Shiao LL, Cascieri MA (1997). "Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.". Biochem. Biophys. Res. Commun. 233 (3): 823–8. doi:10.1006/bbrc.1997.6542. PMID 9168941.  
  • Jacoby AS, Webb GC, Liu ML, et al. (1998). "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene.". Genomics 45 (3): 496–508. doi:10.1006/geno.1997.4960. PMID 9367674.  
  • Lorimer DD, Matkowskj K, Benya RV (1998). "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).". Biochem. Biophys. Res. Commun. 241 (2): 558–64. doi:10.1006/bbrc.1997.7838. PMID 9425310.  
  • Fitzgerald LW, Patterson JP, Conklin DS, et al. (1998). "Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides.". J. Pharmacol. Exp. Ther. 287 (2): 448–56. PMID 9808667.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Henson BS, Neubig RR, Jang I, et al. (2005). "Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma.". J. Biol. Chem. 280 (24): 22564–71. doi:10.1074/jbc.M414589200. PMID 15767248.  
  • Schäuble N, Reichwald K, Grassl W, et al. (2005). "Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity.". J. Nutr. 135 (6): 1387–92. PMID 15930442.  
  • Belfer I, Hipp H, Bollettino A, et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes.". Genes, Brain and Behavior 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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