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Galanin receptor 3
Symbols GALR3;
External IDs OMIM603692 MGI1329003 HomoloGene20798 IUPHAR: GAL3 GeneCards: GALR3 Gene
RNA expression pattern
PBB GE GALR3 33579 i at tn.png
More reference expression data
Species Human Mouse
Entrez 8484 14429
Ensembl ENSG00000128310 ENSMUSG00000047429
UniProt O60755 O88853
RefSeq (mRNA) NM_003614 XM_001001042
RefSeq (protein) NP_003605 XP_001001042
Location (UCSC) Chr 22:
36.55 - 36.55 Mb
Chr 15:
78.87 - 78.87 Mb
PubMed search [1] [2]

Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[1]

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[1]


See also


External links

Further reading

  • Smith KE, Walker MW, Artymyshyn R, et al. (1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.". J. Biol. Chem. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565.  
  • Kolakowski LF, O'Neill GP, Howard AD, et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.". J. Neurochem. 71 (6): 2239–51. PMID 9832121.  
  • Iismaa TP, Fathi Z, Hort YJ, et al. (1999). "Structural organization and chromosomal localization of three human galanin receptor genes.". Ann. N. Y. Acad. Sci. 863: 56–63. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159.  
  • Lapsys NM, Furler SM, Henderson NK, et al. (1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3).". Mol. Cell. Probes 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207.  
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.  
  • Berger A, Tuechler C, Almer D, et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors.". Neuroendocrinology 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941.  
  • Belfer I, Hipp H, Bollettino A, et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes.". Genes, Brain and Behavior 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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