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Galmic
Systematic (IUPAC) name
 ?
Identifiers
CAS number  ?
ATC code  ?
PubChem 11636593
Chemical data
Formula C 51H60N10O11  
Mol. mass 989.080
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1] It has anticonvulsant, antidepressant and analgesic effects in animal studies,[2] but also inhibits memory functions.[3]

References

  1. ^ Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). "Synthesis of galmic: a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 101 (48): 16727–32. doi:10.1073/pnas.0407543101. PMID 15557002.  
  2. ^ Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). "Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests". Proceedings of the National Academy of Sciences of the United States of America 101 (28): 10470–5. doi:10.1073/pnas.0403802101. PMID 15240875.  
  3. ^ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID 15944018.  
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