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Galnon
Systematic (IUPAC) name
9H-​fluoren-​9-​ylmethyl N-​[(2S)-​1-​([(2S)-​6-​amino-​1-​[(4-​methyl-​2-​oxochromen-​7-​ yl)amino]-​1-​oxohexan-​2-​yl]amino)-​3-cyclohexyl-​1-​oxopropan-​2-​yl]carbamate
Identifiers
CAS number 475115-35-6
ATC code  ?
PubChem 5311268
Chemical data
Formula C 40H46N4O6  
Mol. mass 678.815
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1][2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.[3][4][5][6][7]

References

  1. ^ Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U (May 2002). "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7136–41. doi:10.1073/pnas.102163499. PMID 12011470.  
  2. ^ Sollenberg U, Bartfai T, Langel U (June 2005). "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides 39 (3): 161–3. doi:10.1016/j.npep.2004.12.019. PMID 15944006.  
  3. ^ Abramov U, Florén A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U (February 2004). "Regulation of feeding by galnon". Neuropeptides 38 (1): 55–61. doi:10.1016/j.npep.2004.01.001. PMID 15003717.  
  4. ^ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. doi:10.1016/j.npep.2004.12.010. PMID 15944018.  
  5. ^ Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE (October 2007). "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides 41 (5): 307–20. doi:10.1016/j.npep.2007.05.001. PMID 17637475.  
  6. ^ Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H (March 2009). "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry 65 (5): 383–91. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221.  
  7. ^ Narasimhaiah R, Kamens HM, Picciotto MR (May 2009). "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology 204 (1): 95–102. doi:10.1007/s00213-008-1438-7. PMID 19099295.  
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