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Gamma-glutamyl carboxylase: Wikis

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Gamma-glutamyl carboxylase
Identifiers
Symbols GGCX; FLJ26629; VKCFD1
External IDs OMIM137167 MGI1927655 HomoloGene639 GeneCards: GGCX Gene
RNA expression pattern
PBB GE GGCX 205351 at tn.png
PBB GE GGCX 214006 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2677 56316
Ensembl ENSG00000115486 ENSMUSG00000053460
UniProt P38435 Q3TME3
RefSeq (mRNA) NM_000821 NM_019802
RefSeq (protein) NP_000812 NP_062776
Location (UCSC) Chr 2:
85.63 - 85.64 Mb
Chr 6:
72.34 - 72.36 Mb
PubMed search [1] [2]

Gamma-glutamyl carboxylase is an enzyme which in humans is encoded by the GGCX gene.[1]

Contents

Function

This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis.[2] Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational modification.[3] In humans, the gamma-glutamyl carboxylase enzyme is most highly expressed in the liver.

Catalytic reaction

Gamma-glutamyl carboxylase is an enzyme which oxidizes Vitamin K hydroquinone to Vitamin K 2,3 epoxide, while simultaneously adding CO2 to protein-bound glutamic acid (abbreviation = Glu) to form gamma-carboxyglutamic acid (also called gamma-carboxyglutamate, abbreviation = Gla). The carboxylation reaction will only proceed if the carboxylase enzyme is able to oxidize vitamin K hydroquinone to vitamin K epoxide at the same time; the carboxylation and epoxidation reactions are said to be coupled reactions.[4][5][6]

Clinical significance

Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency.[2][7]

See also

References

  1. ^ Wu SM, Cheung WF, Frazier D, Stafford DW (December 1991). "Cloning and expression of the cDNA for human gamma-glutamyl carboxylase". Science (journal) 254 (5038): 1634–6. doi:10.1126/science.1749935. PMID 1749935.  
  2. ^ a b "Entrez Gene: GGCX". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2677.  
  3. ^ Brenner B, Tavori S, Zivelin A, Keller CB, Suttie JW, Tatarsky I, Seligsohn U (August 1990). "Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulants". Br. J. Haematol. 75 (4): 537–42. PMID 2145029.  
  4. ^ Suttie JW (1985). "Vitamin K-dependent carboxylase". Annu. Rev. Biochem. 54: 459–77. doi:10.1146/annurev.bi.54.070185.002331. PMID 3896125.  
  5. ^ Presnell SR, Stafford DW (2002). "The vitamin K-dependent carboxylase". Thromb. Haemost. 87 (6): 937–46. PMID 12083499.  
  6. ^ Silva PJ, Ramos MJ (2007). "Reaction mechanism of the vitamin K-dependent glutamate carboxylase: a computational study". J Phys Chem B 111 (44): 12883–7. doi:10.1021/jp0738208. PMID 17935315.  
  7. ^ Vanakker OM, Martin L, Gheduzzi D, Leroy BP, Loeys BL, Guerci VI, Matthys D, Terry SF, Coucke PJ, Pasquali-Ronchetti I, De Paepe A (March 2007). "Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity". J. Invest. Dermatol. 127 (3): 581–7. doi:10.1038/sj.jid.5700610. PMID 17110937.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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