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Gastric inhibitory polypeptide receptor: Wikis


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From Wikipedia, the free encyclopedia

Gastric inhibitory polypeptide receptor
Symbols GIPR; MGC126722
External IDs OMIM137241 MGI1352753 HomoloGene20081 IUPHAR: GIP GeneCards: GIPR Gene
RNA expression pattern
PBB GE GIPR 208105 at tn.png
More reference expression data
Species Human Mouse
Entrez 2696 381853
Ensembl ENSG00000010310 ENSMUSG00000030406
UniProt P48546 n/a
RefSeq (mRNA) NM_000164 XM_133238
RefSeq (protein) NP_000155 XP_133238
Location (UCSC) Chr 19:
50.86 - 50.88 Mb
Chr 7:
18.32 - 18.32 Mb
PubMed search [1] [2]

Gastric inhibitory polypeptide receptors (GIPRs) are seven-transmembrane proteins found on beta-cells in the pancreas.[1][2]

They bind gastric inhibitory polypeptide.


Further reading

  • Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice.". Horm. Metab. Res. 36 (11-12): 771–4. doi:10.1055/s-2004-826162. PMID 15655707.  
  • Stoffel M, Fernald AA, Le Beau MM, Bell GI (1996). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization.". Genomics 28 (3): 607–9. doi:10.1006/geno.1995.1203. PMID 7490109.  
  • Gremlich S, Porret A, Hani EH, et al. (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.". Diabetes 44 (10): 1202–8. PMID 7556958.  
  • Volz A, Göke R, Lankat-Buttgereit B, et al. (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.". FEBS Lett. 373 (1): 23–9. PMID 7589426.  
  • Usdin TB, Mezey E, Button DC, et al. (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.". Endocrinology 133 (6): 2861–70. PMID 8243312.  
  • Yamada Y, Hayami T, Nakamura K, et al. (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.". Genomics 29 (3): 773–6. doi:10.1006/geno.1995.9937. PMID 8575774.  
  • Gallwitz B, Witt M, Morys-Wortmann C, et al. (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1.". Regul. Pept. 63 (1): 17–22. PMID 8795084.  
  • N'Diaye N, Tremblay J, Hamet P, et al. (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome.". J. Clin. Endocrinol. Metab. 83 (8): 2781–5. PMID 9709947.  
  • Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling.". Endocrinology 141 (3): 947–52. PMID 10698169.  
  • Bollag RJ, Zhong Q, Phillips P, et al. (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors.". Endocrinology 141 (3): 1228–35. PMID 10698200.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Baldacchino V, Oble S, Hamet P, et al. (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene.". Endocr. Res. 28 (4): 577. PMID 12530665.  
  • Antonini SR, N'Diaye N, Hamet P, et al. (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS).". Endocr. Res. 28 (4): 755–6. PMID 12530694.  
  • Manhart S, Hinke SA, McIntosh CH, et al. (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.". Biochemistry 42 (10): 3081–8. doi:10.1021/bi026868e. PMID 12627975.  
  • Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1.". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. doi:10.1152/ajpendo.00509.2002. PMID 12721154.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Hansotia T, Baggio LL, Delmeire D, et al. (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.". Diabetes 53 (5): 1326–35. PMID 15111503.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Baldacchino V, Oble S, Hamet P, et al. (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter.". Endocr. Res. 30 (4): 805–6. PMID 15666829.  

External links



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