The Full Wiki

More info on Gevotroline

Gevotroline: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

Gevotroline
Systematic (IUPAC) name
8-fluoro-2-[3-(pyridin-3-yl)propyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Identifiers
CAS number 107266-06-8
ATC code None
PubChem CID 60547
ChemSpider 54579
Chemical data
Formula C19H20FN3 
Mol. mass 309.38 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Gevotroline (WY-47,384) is an atypical antipsychotic with a tricyclic structure which was under development for the treatment of schizophrenia by Wyeth-Ayerst.[1][2][3] It acts as a balanced, modest affinity D2 and 5-HT2 receptor antagonist and also possesses high affinity for the sigma receptor.[2][4][5][6] It was well-tolerated and showed efficacy in phase II clinical trials but was never marketed.[2][3]

Synthesis

[7]

See also

References

  1. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/?id=Z_mfTTIApVEC&printsec=frontcover#. 
  2. ^ a b c Bristol, James A. (1990). Annual Reports in Medicinal Chemistry (Volume 25). Boston: Academic Press. ISBN 0-12-040525-3. http://books.google.com/?id=NZZbEkldeJAC&lpg=PA2&dq=gevotroline&pg=PA2#v=onepage&q. 
  3. ^ a b Stone, T. W.; Stone, Trevor (1996). CNS neurotransmitters and neuromodulators: dopamine. Boca Raton: CRC Press. ISBN 0-8493-7632-7. http://books.google.com/?id=ObG24oxrivEC&lpg=PA187&dq=gevotroline&pg=PA187#v=onepage&q. 
  4. ^ Snyder SH, Largent BL (1989). [Expression error: Unexpected < operator "Receptor mechanisms in antipsychotic drug action: focus on sigma receptors"]. The Journal of Neuropsychiatry and Clinical Neurosciences 1 (1): 7–15. PMID 2577720. 
  5. ^ Matheson GK, Guthrie D, Bauer C, Knowles A, White G, Ruston C (January 1991). [Expression error: Unexpected < operator "Sigma receptor ligands alter concentrations of corticosterone in plasma in the rat"]. Neuropharmacology 30 (1): 79–87. doi:10.1016/0028-3908(91)90046-E. PMID 1675451. 
  6. ^ Gudelsky GA, Nash JF (February 1992). [Expression error: Unexpected < operator "Neuroendocrinological and neurochemical effects of sigma ligands"]. Neuropharmacology 31 (2): 157–62. doi:10.1016/0028-3908(92)90026-L. PMID 1348112. 
  7. ^ Abou-Gharbia, Magid; Patel, Usha R.; Webb, Michael B.; Moyer, John A.; Andree, Terrance H.; Muth, Eric A. (1987). [Expression error: Unexpected < operator "Antipsychotic activity of substituted .gamma.-carbolines"]. Journal of Medicinal Chemistry 30 (10): 1818. doi:10.1021/jm00393a023. PMID 2888898. 
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message