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Visible cavities in later stage tuberculosis; Ghon focuses are smaller.

A Ghon focus is a primary lesion caused by mycobacterium bacilli (tuberculosis) developed in the lung of a previously uninfected individual. It is named for Anton Ghon (1866-1936), an Austrian pathologist.

It is a small area of granulomatous inflammation, only detectable by chest X-ray if it calcifies or grows substantially (see tuberculosis radiology)[1]. Typically these will heal, but in some cases, especially in immunosuppressed patients, it will progress to miliary tuberculosis (so named due to the calcified granulomas resembling millet seeds on a chest X-ray)[1].

The classical location for primary infection is surrounding the lobar fissures, either in the upper part of the lower lobe or lower part of the upper lobe[1].

If the Ghon focus also involves infection of surrounding lymph nodes, it is known as the Ghon's complex or primary complex[1][2].

References

  1. ^ a b c d Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007). Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 516-522 ISBN 978-1-4160-2973-1
  2. ^ http://www.smbs.buffalo.edu/pth600/IMC-Path/y2case/y2ans10.htm
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