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Gidazepam
Systematic (IUPAC) name
2-(9-bromo- 3-oxo- 6-phenyl- 2,5-diazabicyclo [5.4.0] undeca- 5,8,10,12-tetraen- 2-yl) acetohydrazide
Identifiers
CAS number 129186-29-4
ATC code ??
PubChem 121919
DrugBank ?
Chemical data
Formula C 17H15BrN4O2  
Mol. mass 387.2
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV(US)
Routes Oral

Gidazepam is a drug which is an atypical benzodiazepine derivative, developed in the Soviet Union.[1][2] It is a selectively anxiolytic benzodiazepine.[3] It also has therapeutic value in the management of certain cardiovascular disorders.[4][5][6][7][8]

Gidazepam is a prodrug for its active metabolite 7-bromo-5-phenyl-1,2-di-hydro-3H-1,4- benzodiazepine-2-one (desalkylgidazepam).[9][10] It is used as an antianxiety. Its anxiolytic effects can take several hours to manifest after dosing however, as it is the active metabolite which primarily gives the anxiolytic effects.[11]

See also

References

  1. ^ Spasennikov, BA; Spasennikova (Sep 1991). "The new Soviet tranquilizer--gidazepam". Fel'dsher i akusherka 56 (9): 35–7. ISSN 0014-9772. PMID 1684941.  
  2. ^ Neznamov, GG; Koshelev; Voronina; Trofimov (Mar 2002). "Experimental and clinical rationale for complex treatment of mental disorders in clean-up workers of the Chernobyl nuclear plant accident". Eksperimental'naia i klinicheskaia farmakologiia 65 (2): 12–6. ISSN 0869-2092. PMID 12109283.  
  3. ^ Korkhov, VM; Tkachuk; Makan; Pavlovsky; Andronati (Feb 2002). "Affinities of gidazepam and its analogs for mitochondrial benzodiazepine receptors". Journal of receptor and signal transduction research 22 (1-4): 411–20. doi:10.1081/RRS-120014610. ISSN 1079-9893. PMID 12503630.  
  4. ^ Morozov, IS; Barchukov; Neznamov (Jan 1998). "The effect of gidazepam on the cardiovascular system function in patients with neurotic reactions and in healthy subjects under aggravated conditions". Eksperimental'naia i klinicheskaia farmakologiia 61 (1): 30–2. ISSN 0869-2092. PMID 9575408.  
  5. ^ Petrova, TR; Tatarkin (1994). "The neuroregulatory modulation of the hemodynamic reactions to physical loading in patients with cardiac arrhythmias". Terapevticheskii arkhiv 66 (9): 65–8. ISSN 0040-3660. PMID 7992218.  
  6. ^ Skibitskiĭ, VV; Kanorskiĭ (Sep 1993). "New pharmacodynamic effects of gidazepam and befol in patients with cardiac arrhythmias". Eksperimental'naia i klinicheskaia farmakologiia 56 (5): 23–7. ISSN 0869-2092. PMID 7906171.  
  7. ^ Skibitskiĭ, VV; Petrova; Kanorskiĭ (Jun 1992). "Comparative analysis of antiarrhythmic action and electrophysiological effects of a new benzodiazepine derivative gidazepam and ethacizin in arrhythmias of various genesis". Kardiologiia 32 (6): 35–7. ISSN 0022-9040. PMID 1405290.  
  8. ^ Meerson, FZ; Skibitskiĭ (Apr 1992). "Comparative anti-arrhythmia effectiveness of activators of body stress-limiting systems in patients with arrhythmia". Kardiologiia 32 (4): 25–30. ISSN 0022-9040. PMID 1328745.  
  9. ^ Andronati, SA; Zin'kovskiĭ; Totrova; Golovenko; Stankevich; Zhuk (Jan 1992). "Biokinetics of a new prodrug gidazepam and its metabolite". Biulleten' eksperimental'noi biologii i meditsiny 113 (1): 45–7. ISSN 0365-9615. PMID 1356504.  
  10. ^ Kolyvanov, GB; Zherdev; Chirkov; Otabekova; Litvin (May 1993). "Gidazepam biotransformation and pharmacokinetics in different species of animals and man". Eksperimental'naia i klinicheskaia farmakologiia 56 (3): 48–50. ISSN 0869-2092. PMID 8106054.  
  11. ^ Zherdev, VP; Neznamov; Kolyvanov; Litvin; Otabekova (May 1993). "The pharmacokinetic aspects of the clinical action of gidazepam". Eksperimental'naia i klinicheskaia farmakologiia 56 (3): 50–2. ISSN 0869-2092. PMID 8106055.  







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