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Gliadorphin (also known as gluteomorphin) is an opioid peptide which is formed during digestion of the gliadin component of the gluten protein. It is usually broken down into amino acids by digestion enzymes. It has been hypothesized that children with autism have abnormal leakage from the gut of this compound, which then passes into the brain and disrupts brain function. This is partly the basis for the gluten-free, casein-free diet. Studies of this diet have had important methodological flaws and the scientific evidence is not adequate to make treatment recommendations.[1]

  • Structure: Tyr-Pro-Gln-Pro-Gln-Pro-Phe
  • Molecular weight: 875.43 g/mol

References

  1. ^ Christison GW, Ivany K (2006). "Elimination diets in autism spectrum disorders: any wheat amidst the chaff?". J Dev Behav Pediatr 27 (2 Suppl 2): S162–71. doi:10.1097/00004703-200604002-00015. PMID 16685183.  
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