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Glimepiride: Wikis

  

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Glimepiride
Systematic (IUPAC) name
3-ethyl-4-methyl-N-(4-[N-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
Identifiers
CAS number 93479-97-1
ATC code A10BB12
PubChem 3476
DrugBank APRD00381
Chemical data
Formula C24H34N4O5S 
Mol. mass 490.617 g/mol
Pharmacokinetic data
Bioavailability 100%
Protein binding >99.5%
Half life 5 Hours
Excretion Urine & Fecal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral
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Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic drug. It is marketed as Amaryl by Sanofi-Aventis and Glyree by Ipca. Glimepiride is the first third-generation sulfonylurea, and is very potent.

It is sometimes classified as third-generation,[1] and sometimes classified as second-generation.[2]

Contents

Indications

Type 2 diabetes (NIDDM).

Adverse effects

GI disturbance, rarely thrombocytopenia , leukopenia, hemolytic anemia, occasionally allergic reactions occur. In the initial weeks of treatment, the risk of hypoglycemia may be increased.

Contraindications

-Hypersensitivity to glimepiride or other sulfonylureas.

-Pregnancy

Interactions

With NSAIDs like Salicylates, Sulphonamides, Chloramphenicol, coumadin and probencid may potentiate the hypoglycemic action of glimepiride. Thiazides, other diuretic, phothiazides, thyroid products, oral contraceptives, phenytoin tend to produce hyperglycemia.

Pharmacology

With glimepiride GI absorption is complete, with no interference of meals. Significant absorption of glimepiride was seen within 1 hour, and distributed throughout the body, bound to the plasma protein to an extent of 99.5% and it is metabolized by oxidative biotransformation and 60% is excreted in the urine, the remaining being excreted in the feces.

Mechanism of action

Glimepiride lowers the blood glucose level by stimulating pancreatic beta cells to produce more insulin and by inducing increased activity of intracellular insulin receptors.

It is considered a secretagogue.[3]

References

External links








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