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Glucagon-like peptide 1 receptor: Wikis


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Glucagon-like peptide 1 receptor
Symbols GLP1R; MGC138331
External IDs OMIM138032 MGI99571 HomoloGene1558 IUPHAR: GLP-1 GeneCards: GLP1R Gene
RNA expression pattern
PBB GE GLP1R 208401 s at tn.png
PBB GE GLP1R 208390 s at tn.png
PBB GE GLP1R 208391 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2740 14652
Ensembl ENSG00000112164 ENSMUSG00000024027
UniProt P43220 Q104P0
RefSeq (mRNA) NM_002062 XM_001000702
RefSeq (protein) NP_002053 XP_001000702
Location (UCSC) Chr 6:
39.12 - 39.16 Mb
Chr 17:
30.63 - 30.66 Mb
PubMed search [1] [2]

The glucagon-like peptide 1 receptor (GLP1R) is a human gene which resides on chromosome 6.[1][2] The protein encoded by this gene is a member of the glucagon receptor family of G protein-coupled receptors.[3]


Ligand specificity

GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon.[4]

Function and therapeutic potential

GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin.[5] Consequently GLP1R has been suggested as a potential target for the treatment of diabetes.[6]

GLP1R is also expressed in the brain where it is involved in the control of appetite.[7] Furthermore, mice which over express GLP1R display improved memory and learning.[8]

See also


  1. ^ Thorens B (September 1992). "Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8641–5. doi:10.1073/pnas.89.18.8641. PMID 1326760.  
  2. ^ Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE 3rd (October 1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor". Endocrinology 133 (4): 1907–10. doi:10.1210/en.133.4.1907. PMID 8404634.  
  3. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" (PDF). Recept. Channels 8 (3-4): 179–88. doi:10.1080/10606820213687. PMID 12529935. Retrieved 2008-07-14.  
  4. ^ Fehmann HC, Jiang J, Schweinfurth J, Dörsch K, Wheeler MB, Boyd AE 3rd, Göke B (April 1994). "Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells". Z Gastroenterol 32 (4): 203–7. PMID 8017094.  
  5. ^ Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF (May 1987). "Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3434–8. doi:10.1073/pnas.84.10.3434. PMID 3033647.  
  6. ^ Holst JJ (May 2004). "Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors". Expert Opin Emerg Drugs 9 (1): 155–66. doi:10.1517/eoed. PMID 15155141.  
  7. ^ Kinzig KP, D'Alessio DA, Seeley RJ (1 December 2002). "The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness". J. Neurosci. 22 (23): 10470–6. PMID 12451146.  
  8. ^ During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN (September 2003). "Glucagon-like peptide-1 receptor is involved in learning and neuroprotection". Nat. Med. 9 (9): 1173–9. doi:10.1038/nm919. PMID 12925848.  

Further reading

External links



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