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Glucagon-like peptide 2 receptor: Wikis


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From Wikipedia, the free encyclopedia

Glucagon-like peptide 2 receptor
Symbols GLP2R;
External IDs OMIM603659 MGI2136733 HomoloGene3132 IUPHAR: GLP-2 GeneCards: GLP2R Gene
RNA expression pattern
PBB GE GLP2R 221312 at tn.png
More reference expression data
Species Human Mouse
Entrez 9340 93896
Ensembl ENSG00000065325 n/a
UniProt O95838 n/a
RefSeq (mRNA) NM_004246 XM_991784
RefSeq (protein) NP_004237 XP_996878
Location (UCSC) Chr 17:
9.67 - 9.73 Mb
PubMed search [1] [2]

The gene for the glucagon-like peptide 2 receptor (GLP-2) is on chromosome 17.[1]


See also


  1. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" ( – Scholar search). Recept. Channels 8 (3-4): 179–88. doi:10.1080/10606820213687. PMID 12529935. Retrieved 2007-08-24.  

Further reading

  • Burrin DG, Petersen Y, Stoll B, Sangild P (2001). "Glucagon-like peptide 2: a nutrient-responsive gut growth factor.". J. Nutr. 131 (3): 709–12. PMID 11238747.  
  • Munroe DG, Gupta AK, Kooshesh F, et al. (1999). "Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1569–73. doi:10.1073/pnas.96.4.1569. PMID 9990065.  
  • Yusta B, Huang L, Munroe D, et al. (2000). "Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.". Gastroenterology 119 (3): 744–55. doi:10.1053/gast.2000.16489. PMID 10982769.  
  • Thulesen J, Knudsen LB, Hartmann B, et al. (2002). "The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.". Regul. Pept. 103 (1): 9–15. doi:10.1016/S0167-0115(01)00316-0. PMID 11738243.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Koehler JA, Yusta B, Drucker DJ (2005). "The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.". Mol. Endocrinol. 19 (2): 459–73. doi:10.1210/me.2004-0196. PMID 15471943.  
  • Ørskov C, Hartmann B, Poulsen SS, et al. (2005). "GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.". Regul. Pept. 124 (1-3): 105–12. doi:10.1016/j.regpep.2004.07.009. PMID 15544847.  
  • Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850.  
  • Estall JL, Koehler JA, Yusta B, Drucker DJ (2005). "The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.". J. Biol. Chem. 280 (23): 22124–34. doi:10.1074/jbc.M500078200. PMID 15817468.  
  • Guan X, Karpen HE, Stephens J, et al. (2006). "GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.". Gastroenterology 130 (1): 150–64. doi:10.1053/j.gastro.2005.11.005. PMID 16401478.  
  • Sams A, Hastrup S, Andersen M, Thim L (2006). "Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines.". Eur. J. Pharmacol. 532 (1-2): 18–23. doi:10.1016/j.ejphar.2005.12.001. PMID 16448646.  

External links



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