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Glycine transporter 2: Wikis


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Solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Symbols SLC6A5; GLYT2; NET1
External IDs OMIM604159 MGI105090 HomoloGene37901 GeneCards: SLC6A5 Gene
RNA expression pattern
PBB GE SLC6A5 210810 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9152 104245
Ensembl ENSG00000165970 n/a
UniProt Q9Y345 n/a
RefSeq (mRNA) NM_004211 NM_148931
RefSeq (protein) NP_004202 NP_683733
Location (UCSC) Chr 11:
20.58 - 20.63 Mb
PubMed search [1] [2]

Glycine transporter 2 (GlyT2) is a membrane protein which recaptures glycine, a major inhibitory transmitter in the spinal cord and brainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the the Na+ and Cl--coupled transporter familly SLC6. In humans GlyT2 is encoded by the SLC6A5 gene.[1][2]

See also


  1. ^ Morrow JA, Collie IT, Dunbar DR, Walker GB, Shahid M, Hill DR (Dec 1998). "Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome". FEBS Lett 439 (3): 334-40. PMID 9845349. 
  2. ^ "Entrez Gene: SLC6A5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5". 

Further reading

  • López-Corcuera B, Aragón C, Geerlings A (2002). "Regulation of glycine transporters.". Biochem. Soc. Trans. 29 (Pt 6): 742–5. doi:10.1042/BST0290742. PMID 11709067. 
  • Gallagher MJ, Burgess LH, Brunden KR (1999). "Characterization of multiple forms of the human glycine transporter type-2.". Brain Res. Mol. Brain Res. 70 (1): 101–15. doi:10.1016/S0169-328X(99)00135-7. PMID 10381548. 
  • Evans J, Herdon H, Cairns W, et al. (2000). "Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter.". FEBS Lett. 463 (3): 301–6. doi:10.1016/S0014-5793(99)01636-1. PMID 10606742. 
  • Martínez-Maza R, Poyatos I, López-Corcuera B, et al. (2001). "The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2.". J. Biol. Chem. 276 (3): 2168–73. doi:10.1074/jbc.M006774200. PMID 11036075. 
  • Geerlings A, Núñez E, Rodenstein L, et al. (2002). "Glycine transporter isoforms show differential subcellular localization in PC12 cells.". J. Neurochem. 82 (1): 58–65. doi:10.1046/j.1471-4159.2002.00930.x. PMID 12091465. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mahendrasingam S, Wallam CA, Hackney CM (2003). "Two approaches to double post-embedding immunogold labeling of freeze-substituted tissue embedded in low temperature Lowicryl HM20 resin.". Brain Res. Brain Res. Protoc. 11 (2): 134–41. doi:10.1016/S1385-299X(03)00040-0. PMID 12738009. 
  • Baliova M, Betz H, Jursky F (2004). "Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2.". J. Neurochem. 88 (1): 227–32. PMID 14675166. 
  • Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMID 15124103. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Jamra RA, Villela AW, Klein K, et al. (2006). "No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia.". Psychiatr. Genet. 16 (3): 91. doi:10.1097/01.ypg.0000199450.07786.ab. PMID 16691125. 
  • Rees MI, Harvey K, Pearce BR, et al. (2006). "Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease.". Nat. Genet. 38 (7): 801–6. doi:10.1038/ng1814. PMID 16751771. 
  • Eulenburg V, Becker K, Gomeza J, et al. (2006). "Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia.". Biochem. Biophys. Res. Commun. 348 (2): 400–5. doi:10.1016/j.bbrc.2006.07.080. PMID 16884688. 


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