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Glycoprotein Ib: Wikis

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Glycoprotein Ib, abbreviated to GPIb is a component of the GPIb-V-IX complex on platelets. It is deficient in the Bernard-Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand's disease[1]

It is also known as "CD42".[2]

Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.[3]

Components include GP1BA and GP1BB.

It complexes with Glycoprotein IX.

References

  1. ^ McPherson & Pincus: Henry's Clinical Diagnosis and Management by Laboratory Methods, 21st ed., pp. 760-2 (W.B. Saunders, 2006).
  2. ^ Bode AP, Read MS, Reddick RL (February 1999). "Activation and adherence of lyophilized human platelets on canine vessel strips in the Baumgartner perfusion chamber". J. Lab. Clin. Med. 133 (2): 200–11. PMID 9989772. http://linkinghub.elsevier.com/retrieve/pii/S0022-2143(99)90013-6.  
  3. ^ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470. http://linkinghub.elsevier.com/retrieve/pii/S0037-1963(07)00159-X.  

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