Godkiller is a transmedia series of graphic novels, illustrated films, and novels created by award-winning filmmaker Matt Pizzolo that tells the stories of human beings caught in the crossfire of warring fallen gods.
The October 2009 illustrated film DVD Godkiller: Walk Among Us - Episode 1 quickly established itself as its distributor's all-time fastest selling release.
When Fangoria asked about the inspiration behind Godkiller, Pizzolo stated:
"I thought it would be fun to design a new mythology for fuck-ups and misfits." 
The illustrated film format Pizzolo developed with producer Brian Giberson for Godkiller merges sequential art with 3D CGI, motion graphics and dramatic voice performances in the style of a radio play.
Wired asked Pizzolo to explain the differences between motion comics and illustrated films:
"In illustrated films, we drive the pace of the storytelling with the dramatic voice performances and the sound design, so that allows us to showcase the illustrations in a way where you can really take a moment to absorb the art in the same way you can when reading a comic book... Motion comics are closer to a form of limited animation that uses comics as source material. Illustrated films are closer to the experimental cinema of Ralph Bakshi’s work, Chris Marker’s La Jetée or animation like Liquid Television." 
The Godkiller series made its debut with the graphic novel Godkiller: Walk Among Us (written by Pizzolo, illustrated by Anna Muckcracker), a post-apocalyptic tale that is currently being adapted into an illustrated film by HALO 8 Entertainment. Pizzolo is currently writing the pre-apocalyptic prequel Godkiller: Silent War, an urban fantasy novel which will debut as a series of audiobooks on the GK: Walk Among Us dvds. 
Pizzolo explained the dramatic structure to Dread Central:
"Godkiller is split into two periods... there's the pre-nuke world of Silent War and there's the post-nuke world of the graphic novel and illustrated film Walk Among Us. So Silent War is only a prequel insofar as it happens beforehand, but its events drive the Walk Among Us story, and many of the same characters appear in both. I'm super excited that the two stories can roll out together in this integrated way--everything about this project is unorthodox and crazy, hopefully everyone will enjoy the ride." 
The illustrated film was initially slated for a unique release model of limited-edition, bi-monthly episodic DVDs starting September 29th 2009, followed by a theatrical run of the full feature in January 2010 and a DVD/Blu-ray release of the full feature in March 2010.
Due to overwhelming retail demand far beyond studio expectations, the first episodic DVD's street date was delayed a week until October 6, 2009 so enough DVDs could be manufactured to supply stores including Best Buy, Hot Topic, Borders Books, F.Y.E., Suncoast, Wherehouse Music, Newbury Comics, Amoeba Music, Rasputin Records, Dimple Records, Waterloo Records, J&R Electronics, Silver Platters, Zia Records, and many more. Due to retail holiday conflicts, this delay rescheduled the entire release to: Episode 1 Oct 6 2009, Episode 2 Jan 26 2010, Episode 3 Mar 30 2010 (with day & date theatrical release of full feature), Complete DVD/Bu-ray May 25 2010.
[Pre-nuke period] In the near future, 17-year-old Joe Junior and his girlfriend Bee run a speakeasy in the basement of an abandoned NYC church where they serve narcotic drinks to underagers while providing sanctuary and black-market employment to draft dodgers. When Joe is recruited by an armed cult of populist assassins, he is thrust into a secret world of international cabals, alien conspiracies, and the countdown to Armageddon.
[Post-nuke period] Set in the future after an economic collapse, a nuclear holy war and an alien invasion, Godkiller: Walk Among Us follows orphan Tommy as he searches for a new heart for his ill sister, Lucy.
Pizzolo developed the concept of an illustrated film with his producing partner Brian Giberson, mixing elements of anime, radio drama, video games, and motion comics. Utilizing the original artwork from the comic book, the illustrated film adds motion animation, visual effects, elaborate sound design, music, and voice-acting performances.
Explaining the decision to develop the new filmmaking format, Pizzolo told Bloody Disgusting: 
"When we decided to make an anime adaptation of the comic book, I couldn't see how a traditional animated approach would do justice to Anna's incredibly lush and detailed illustrations. It made perfect sense to adapt the medium to suit her art, rather than vice versa." 
Pizzolo clarified further in an interview with Horror News:
"There are lots of reasons [Godkiller was made as an illustrated film], but I think the most important one was really being inspired by Anna Muckcracker's gorgeous artwork. Brian Giberson (my partner at Halo-8) and I had been experimenting with the illustrated film format for a while, but we might still have gone with traditional animation for Godkiller since it's really risky to experiment with a crazy story and a new filmmaking format at the same time. But once I saw Anna's art I knew that no traditional form of animation could do justice to the grimy, textured, surreal aesthetic she created. It was really an artistic choice, because from a business point of view it's just so risky." 
According to Fangoria, "Lance Henriksen, Bill Moseley and Tiffany Shepis are the genre stalwarts lending their vocal talents to the project; also on board in that capacity are underground cinema queen Lydia Lunch and singers Justin Pierre (of Motion City Soundtrack) and Davey Havok (of A.F.I.)." 
Pizzolo and Giberson unveiled a preview clip of the Godkiller illustrated film during the "Comic Books & Indie Movies" panel at Comic-Con International's Wondercon in San Francisco on February 28, 2009.    
According to Shock Till You Drop, "Danielle Harris (known for her turns in the Halloween franchise), Katie Nisa (Threat), and Nicki Clyne (Battlestar Galactica) have joined previously announced cast members Lance Henriksen, Bill Moseley, Tiffany Shepis, Justin Pierre (singer of Motion City Soundtrack), Lydia Lunch (Richard Kern's 'Hardcore Collection'), and Davey Havok (A.F.I.) in the cast of the 'illustrated film' adaptation Godkiller, written and directed by award-winning filmmaker Matt Pizzolo (Threat) based on the comic book he created with illustrator Anna Muckcracker." 
Pizzolo, Giberson and actresses Danielle Harris and Tiffany Shepis presented two exclusive preview clips of the Godkiller illustrated film at Fangoria's Weekend of Horrors in Los Angeles on April 18, 2009.