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Gradenigo's syndrome
Classification and external resources
ICD-9 383.02
DiseasesDB 32176

Gradenigo's syndrome, also called Gradenigo-Lannois syndrome[1][2] and petrous apicitis, is a complication of otitis media and mastoiditis involving the apex of the petrous temporal bone.


Symptoms of the syndrome include:

Other symptoms can include photophobia, excessive lacrimation, fever, and reduced corneal sensitivity.
The syndrome is usually caused by the spread of an infection into the petrous apex of the temporal bone.


It is named after Count Giuseppe Gradenigo, an Italian Otolaryngologist, and Maurice Lannois.[3]


  1. ^ Devic M, Boucher M, Raveau M (Apr 1966). "Some cases of Gradenigo-Lannois syndrome". Journal de medecine de Lyon 47 (96): 537–547. ISSN 0021-7883. PMID 4286558.  
  2. ^ Bléry M, Chagnon S, Picard A, Babin C (Nov 1980). "Cranial osteitis: a report on four cases, including a Gradenigo-Lannois syndrome (author's transl)". Journal de radiologie 61 (11): 677–681. ISSN 0221-0363. PMID 7452536.  
  3. ^ synd/738 at Who Named It?


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