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Growth factor receptor-bound protein 2

PDB rendering based on 1gri.
Available structures
1aze, 1bm2, 1bmb, 1cj1, 1fhs, 1fyr, 1gbq, 1gbr, 1gcq, 1gfc, 1gfd, 1ghu, 1gri, 1io6, 1jyq, 1jyr, 1jyu, 1qg1, 1tze, 1x0n, 1zfp, 2aoa, 2aob, 2gbq, 2h46, 2h5k, 2huw, 2huy, 3gbq, 4gbq
Symbols GRB2; ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084
External IDs OMIM108355 MGI95805 HomoloGene1576 GeneCards: GRB2 Gene
RNA expression pattern
PBB GE GRB2 215075 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2885 14784
Ensembl ENSG00000177885 ENSMUSG00000059923
UniProt P62993 Q3U1Q4
RefSeq (mRNA) NM_002086 NM_008163
RefSeq (protein) NP_002077 NP_032189
Location (UCSC) Chr 17:
70.83 - 70.91 Mb
Chr 11:
115.46 - 115.52 Mb
PubMed search [1] [2]

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.[1][2]

The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]


Function and expression

Grb2 is widely expressed and is essential for multiple cellular functions. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types, and so it is not surprising that a targeted gene disruption of Grb2 in mouse is lethal at an early embryonic stage. Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely related proteins with similar domain organizations, Gads and Grap. Gads and Grap are expressed specifically in hematopoietic cells and function in the coordination of tyrosine kinase mediated signal transduction.


The SH2 domain of Grb2 binds to phosphorylated tyrosine-containing peptides on receptors or scaffold proteins with a preference for pY-X-N-X, where X is generally a hydrophobic residue such as valine (see The SH2 Website).

The N-terminal SH3 domain binds to proline-rich peptide peptides and can bind to the Ras-guanine exchange factor SOS.

The C-terminal SH3 domain binds to peptides conforming to a P-X-I/L/V/-D/N-R-X-X-K-P motif that allows it to specifically bind to proteins such as Gab-1.[4]


Grb2 has been shown to interact with Arachidonate 5-lipoxygenase,[5][6] Lymphocyte cytosolic protein 2,[7][8][9][10][11] GAB2,[12][13][14] B-cell linker,[15][16][17][18] Abl gene,[19][20] CD28,[21][22] FRS2,[23][24][25][26] Mitogen-activated protein kinase 9,[27][28] CD22,[29][30] NEU3,[31] ETV6,[12] MAP2,[32][33] Dock180,[34][35] PIK3R1,[36][37] SH2B1,[38][39] CRK,[40][41][42] GAB1,[43][7][44] MST1R,[45][46] DNM1,[47][48] Huntingtin,[49] Src,[50][51] Beta-2 adrenergic receptor,[52] VAV2,[53][54] ADAM15,[55] RAPGEF1,[56][57] VAV1,[58][59][60][61] HER2/neu,[62][54][63] Epidermal growth factor receptor,[62][53][43][64][65][66][67][68][2][69] PDGFRB,[70][71][69] PTK2,[72][73][74][75][76] Erythropoietin receptor,[77][78] Linker of activated T cells,[79][80][81] Dystroglycan,[82] SH3KBP1,[83][84] Granulocyte colony-stimulating factor receptor,[85] DCTN1,[86] CDKN1B,[87] Colony stimulating factor 1 receptor,[88] EPH receptor A2,[89] KHDRBS1,[90][43][91] RET proto-oncogene,[92][93] PLCG1,[94][95][96] TrkA,[97][98] PRKAR1A,[66] Janus kinase 2,[99][100] MUC1,[101] CD117,[102][103][78] Fas ligand,[104][105] Janus kinase 1,[106][100] VAV3,[53][107] BCAR1,[108][73] PTPN1,[109][110] INPP5D,[111] ITK,[112][113] SHC1,[53][114][115][116][117][118][119][120][121][122][123][124][125][126][51][127][128][129][130][131][132] PTPN12,[133] C-Met,[134][135] PTPN11,[136][137][85][138][71][139][140][127][141] Glycoprotein 130,[61] PTPN6,[136][142][51] Syk,[136][51] MAP4K1,[143][144][145][146] Wiskott-Aldrich syndrome protein,[147][148] NCKIPSD,[149][150] PTPRA,[151][152][153] BCR gene,[154][155][12][115][156][157] CBLB,[158][159][160] Cbl gene,[161][90][158][24][162][163][124][9][164][165][51][166][167] SOS1,[53][90][43][115][8][168][24][169][170][95][101][68][171][122][42][60][124][172][51][48][131] IRS1,[114][173][100] TNK2,[116][174] MED28,[175] MAP3K1[176] and HNRNPC.[177]

See also


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Further reading

  • Colledge M, Froehner SC (1998). "Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.". Ann. N. Y. Acad. Sci. 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219.  
  • Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). "Waltzing with WASP.". Trends Cell Biol. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612.  
  • O'Sullivan E, Kinnon C, Brickell P (1999). "Wiskott-Aldrich syndrome protein, WASP.". Int. J. Biochem. Cell Biol. 31 (3-4): 383–7. doi:10.1016/S1357-2725(98)00118-6. PMID 10224664.  
  • Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase.". Prog. Biophys. Mol. Biol. 71 (3-4): 435–78. doi:10.1016/S0079-6107(98)00052-2. PMID 10354709.  
  • Vidal M, Liu WQ, Gril B, et al. (2004). "[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]". J. Soc. Biol. 198 (2): 133–7. PMID 15368963.  

External links



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