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Group C GPCR family: Wikis

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7 transmembrane receptor (metabotropic glutamate family)
Identifiers
Symbol 7tm_3
Pfam PF00003
InterPro IPR000337
PROSITE PDOC00754

The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors.[1]

Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.

Contents

Subfamilies

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Calcium-sensing receptor-related

GABAB receptors

Metabotropic glutamate receptors

RAIG

Taste receptors

Orphan

Other

References

  1. ^ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.  

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