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Gs alpha subunit: Wikis


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GNAS complex locus
Symbol GNAS
Alt. symbols GNAS1
Entrez 2778
HUGO 4392
OMIM 139320
RefSeq NM_000516
UniProt Q5JWF2
Other data
Locus Chr. 20 q13.2-13.3

The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP dependent pathway by activating adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [1]



The G-protein coupled receptors that couple to this kind of G-protein include:


The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.

It provides a step in signal transduction. Amplification of the signal occurs for instance because the receptor activates several Gs. [2] However, each Gs activates only one adenylate cyclase.[2]

See also

External links


  1. ^ Health Blog Posts powered by BlogBurst |
  2. ^ a b Page 155 in: Purves (2007). Neuroscience, 4th Edition. Sinauer Associates Inc. ISBN 9780878936977.  


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