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Guanadrel
Guanadrel.png
IUPAC name
Identifiers
CAS number 40580-59-4
PubChem 38521
SMILES
Properties
Molecular formula C10H19N3O2
Molar mass 213.27676
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Guanadrel is an antihypertensive agent.[1]

Mechanism of action

Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump; guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation. The reduction in neurotransmitter release in response to sympathetic nerve stimulation, as a result of catecholamine depletion, leads to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position. Guanadrel is rapidly and well absorbed from gastrointestinal tract.[2]

In 1981 the JAMA reported guanadrel as an effective step II or step III treatment of hypertension.[3]

References

  1. ^ Oren A, Rotmensch HH, Vlasses PH, et al. (1985). "A dose-titration trial of guanadrel as step-two therapy in essential hypertension". J Clin Pharmacol 25 (5): 343–6. PMID 4031111. http://jcp.sagepub.com/cgi/pmidlookup?view=long&pmid=4031111.  
  2. ^ Guanadrel, from Pharmacogenetics Knowledge Base
  3. ^ M. I. Dunn and J. L. Dunlap (1981). "Guanadrel. A new antihypertensive drug". JAMA 245 (16). http://jama.ama-assn.org/cgi/content/abstract/245/16/1639.  

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