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Hyaluronan binding protein 2
Identifiers
Symbols HABP2; FSAP; HABP; HGFAL; PHBP
External IDs OMIM603924 MGI1196378 HomoloGene3050 GeneCards: HABP2 Gene
RNA expression pattern
PBB GE HABP2 206010 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3026 226243
Ensembl ENSG00000148702 ENSMUSG00000025075
UniProt Q14520 Q3UEI7
RefSeq (mRNA) NM_004132 NM_146101
RefSeq (protein) NP_004123 NP_666213
Location (UCSC) Chr 10:
115.3 - 115.34 Mb
Chr 19:
56.34 - 56.37 Mb
PubMed search [1] [2]

Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene.[1][2][3]

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.[3]

References

  1. ^ Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M (Dec 1996). "Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem 119 (6): 1157-65. PMID 8827452.  
  2. ^ Romisch J (Nov 2002). "Factor VII activating protease (FSAP): a novel protease in hemostasis". Biol Chem 383 (7-8): 1119-24. doi:10.1515/BC.2002.121. PMID 12437095.  
  3. ^ a b "Entrez Gene: HABP2 hyaluronan binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3026.  

Further reading

  • Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.  
  • Sumiya J, Asakawa S, Tobe T, et al. (1998). "Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) gene (HABP2).". J. Biochem. 122 (5): 983–90. PMID 9443814.  
  • Choi-Miura NH, Yoda M, Saito K, et al. (2001). "Identification of the substrates for plasma hyaluronan binding protein.". Biol. Pharm. Bull. 24 (2): 140–3. doi:10.1248/bpb.24.140. PMID 11217080.  
  • Choi-Miura NH, Takahashi K, Yoda M, et al. (2001). "Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein.". Biol. Pharm. Bull. 24 (5): 448–52. doi:10.1248/bpb.24.448. PMID 11379758.  
  • Roemisch J, Feussner A, Nerlich C, et al. (2003). "The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP).". Blood Coagul. Fibrinolysis 13 (5): 433–41. doi:10.1097/00001721-200207000-00008. PMID 12138371.  
  • Wang KK, Liu N, Radulovich N, et al. (2002). "Novel candidate tumor marker genes for lung adenocarcinoma.". Oncogene 21 (49): 7598–604. doi:10.1038/sj.onc.1205953. PMID 12386823.  
  • Etscheid M, Beer N, Fink E, et al. (2003). "The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin.". Biol. Chem. 383 (10): 1633–43. doi:10.1515/BC.2002.184. PMID 12452440.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Willeit J, Kiechl S, Weimer T, et al. (2003). "Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis.". Circulation 107 (5): 667–70. doi:10.1161/01.CIR.0000055189.18831.B1. PMID 12578864.  
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.  
  • Hoppe B, Tolou F, Radtke H, et al. (2005). "Marburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism.". Blood 105 (4): 1549–51. doi:10.1182/blood-2004-08-3328. PMID 15486068.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ireland H, Miller GJ, Webb KE, et al. (2005). "The factor VII activating protease G511E (Marburg) variant and cardiovascular risk.". Thromb. Haemost. 92 (5): 986–92. doi:10.1267/THRO04050986. PMID 15543324.  
  • Nakazawa F, Kannemeier C, Shibamiya A, et al. (2005). "Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP).". Biochem. J. 385 (Pt 3): 831–8. doi:10.1042/BJ20041021. PMID 15654766.  
  • van Minkelen R, de Visser MC, Vos HL, et al. (2005). "The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis.". Blood 105 (12): 4898; author reply 4899. doi:10.1182/blood-2005-02-0576. PMID 15933067.  
  • Etscheid M, Beer N, Dodt J (2006). "The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration.". Cell. Signal. 17 (12): 1486–94. doi:10.1016/j.cellsig.2005.03.007. PMID 16153533.  
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