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Hyaluronan synthase 3
Symbols HAS3;
External IDs OMIM602428 MGI109599 HomoloGene68461 GeneCards: HAS3 Gene
Species Human Mouse
Entrez 3038 15118
Ensembl ENSG00000103044 ENSMUSG00000031910
UniProt O00219 Q8CEB9
RefSeq (mRNA) NM_005329 XM_994700
RefSeq (protein) NP_005320 XP_999794
Location (UCSC) Chr 16:
67.7 - 67.71 Mb
Chr 8:
109.76 - 109.77 Mb
PubMed search [1] [2]

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.[1][2][3]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.[3]


  1. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics 41 (3): 493-7. doi:10.1006/geno.1997.4696. PMID 9169154.  
  2. ^ Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem 272 (14): 8957-61. PMID 9083017.  
  3. ^ a b "Entrez Gene: HAS3 hyaluronan synthase 3".  

Further reading

  • Jacobson A, Brinck J, Briskin MJ, et al. (2000). "Expression of human hyaluronan synthases in response to external stimuli.". Biochem. J. 348 Pt 1: 29–35. doi:10.1042/0264-6021:3480029. PMID 10794710.  
  • Simpson MA, Reiland J, Burger SR, et al. (2001). "Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.". J. Biol. Chem. 276 (21): 17949–57. doi:10.1074/jbc.M010064200. PMID 11278609.  
  • Kuroda K, Utani A, Hamasaki Y, Shinkai H (2001). "Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts.". J. Dermatol. Sci. 26 (2): 156–60. doi:10.1016/S0923-1811(00)00155-9. PMID 11378333.  
  • Liu N, Gao F, Han Z, et al. (2001). "Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.". Cancer Res. 61 (13): 5207–14. PMID 11431361.  
  • Simpson MA, Wilson CM, Furcht LT, et al. (2002). "Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.". J. Biol. Chem. 277 (12): 10050–7. doi:10.1074/jbc.M110069200. PMID 11790779.  
  • Sayo T, Sugiyama Y, Takahashi Y, et al. (2002). "Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes.". J. Invest. Dermatol. 118 (1): 43–8. doi:10.1046/j.0022-202x.2001.01613.x. PMID 11851874.  
  • Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMID 12417987.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bullard KM, Kim HR, Wheeler MA, et al. (2004). "Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth.". Int. J. Cancer 107 (5): 739–46. doi:10.1002/ijc.11475. PMID 14566823.  
  • Suzuki K, Yamamoto T, Usui T, et al. (2004). "Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.". Jpn. J. Ophthalmol. 47 (6): 557–64. doi:10.1016/j.jjo.2003.09.001. PMID 14636845.  
  • Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). "Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells.". Biochim. Biophys. Acta 1760 (6): 890–5. doi:10.1016/j.bbagen.2006.02.002. PMID 16564133.  
  • Campo GM, Avenoso A, Campo S, et al. (2007). "TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate.". Mol. Cell. Biochem. 292 (1-2): 169–78. doi:10.1007/s11010-006-9230-7. PMID 16786194.  


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