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HMG-box transcription factor 1

PDB rendering based on 1v06.
Available structures
Symbols HBP1; FLJ16340
External IDs MGI894659 HomoloGene8171 GeneCards: HBP1 Gene
RNA expression pattern
PBB GE HBP1 209102 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26959 73389
Ensembl ENSG00000105856 ENSMUSG00000002996
UniProt O60381 Q3UQS1
RefSeq (mRNA) NM_012257 NM_153198
RefSeq (protein) NP_036389 NP_694878
Location (UCSC) Chr 7:
106.6 - 106.63 Mb
Chr 12:
32.51 - 32.54 Mb
PubMed search [1] [2]

HMG-box transcription factor 1, also known as HBP1, is a human protein.[1]



HBP1 has been shown to interact with SIN3A[2] and Retinoblastoma protein.[3]


  1. ^ "Entrez Gene: HBP1 HMG-box transcription factor 1".  
  2. ^ Swanson, Kurt A; Knoepfler Paul S, Huang Kai, Kang Richard S, Cowley Shaun M, Laherty Carol D, Eisenman Robert N, Radhakrishnan Ishwar (Aug. 2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nat. Struct. Mol. Biol. (United States) 11 (8): 738–46. doi:10.1038/nsmb798. ISSN 1545-9993. PMID 15235594.  
  3. ^ Lavender, P; Vandel L, Bannister A J, Kouzarides T (Jun. 1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene (ENGLAND) 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. ISSN 0950-9232. PMID 9178770.  

Further reading

  • Tevosian SG, Shih HH, Mendelson KG, et al. (1997). "HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.". Genes Dev. 11 (3): 383–96. doi:10.1101/gad.11.3.383. PMID 9030690.  
  • Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.". Oncogene 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.  
  • Zhuma T, Tyrrell R, Sekkali B, et al. (2000). "Human HMG box transcription factor HBP1: a role in hCD2 LCR function.". EMBO J. 18 (22): 6396–406. doi:10.1093/emboj/18.22.6396. PMID 10562551.  
  • Lemercier C, Duncliffe K, Boibessot I, et al. (2000). "Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.". Mol. Cell. Biol. 20 (18): 6627–37. doi:10.1128/MCB.20.18.6627-6637.2000. PMID 10958660.  
  • Shih HH, Xiu M, Berasi SP, et al. (2001). "HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue.". Mol. Cell. Biol. 21 (17): 5723–32. doi:10.1128/MCB.21.17.5723-5732.2001. PMID 11486012.  
  • Sampson EM, Haque ZK, Ku MC, et al. (2001). "Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.". EMBO J. 20 (16): 4500–11. doi:10.1093/emboj/20.16.4500. PMID 11500377.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • de Chiara C, Kelly G, Frenkiel TA, Pastore A (2004). "Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1.". J. Biomol. NMR 28 (4): 411–2. doi:10.1023/B:JNMR.0000015367.92295.0f. PMID 14872137.  
  • Berasi SP, Xiu M, Yee AS, Paulson KE (2004). "HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase.". Mol. Cell. Biol. 24 (7): 3011–24. doi:10.1128/MCB.24.7.3011-3024.2004. PMID 15024088.  
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.  
  • Swanson KA, Knoepfler PS, Huang K, et al. (2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations.". Nat. Struct. Mol. Biol. 11 (8): 738–46. doi:10.1038/nsmb798. PMID 15235594.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Yao CJ, Works K, Romagnoli PA, Austin GE (2005). "Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells.". Leukemia 19 (11): 1958–68. doi:10.1038/sj.leu.2403918. PMID 16179914.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Sekkali B, Szabat E, Ktistaki E, et al. (2005). "Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation.". J. Immunol. 175 (8): 5203–12. PMID 16210625.  
  • Kim J, Zhang X, Rieger-Christ KM, et al. (2006). "Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1.". J. Biol. Chem. 281 (16): 10865–75. doi:10.1074/jbc.M513378200. PMID 16495219.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  
  • Zhang X, Kim J, Ruthazer R, et al. (2007). "The HBP1 transcriptional repressor participates in RAS-induced premature senescence.". Mol. Cell. Biol. 26 (22): 8252–66. doi:10.1128/MCB.00604-06. PMID 16966377.  

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