HDAC3: Wikis


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Histone deacetylase 3
Symbols HDAC3; RPD3; HD3; RPD3-2
External IDs OMIM605166 MGI1343091 HomoloGene48250 GeneCards: HDAC3 Gene
RNA expression pattern
PBB GE HDAC3 216326 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8841 15183
Ensembl ENSG00000171720 ENSMUSG00000024454
UniProt O15379 Q3UM33
RefSeq (mRNA) NM_003883 NM_010411
RefSeq (protein) NP_003874 NP_034541
Location (UCSC) Chr 5:
140.98 - 141 Mb
Chr 18:
38.06 - 38.08 Mb
PubMed search [1] [2]

Histone deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene.[1][2]

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.[3]



HDAC3 has been shown to interact with HDAC9,[4][5] HDAC7A,[6] Retinoblastoma protein,[7][8] RBBP4,[9] Testicular receptor 2,[10][11][12] MAP3K7IP2,[13] Peroxisome proliferator-activated receptor delta,[11][14] GTF2I,[15][16] Histone deacetylase 5,[17][18][19][20] RELA,[21] MAPK11,[22] TBL1X,[19][23] Nuclear receptor co-repressor 1,[24][25][18][6][19][26][27] Cyclin D1,[28][29] Nuclear receptor co-repressor 2,[24][25][23][18][30][26][27] ZBTB33,[24] SUV39H1,[31] Peroxisome proliferator-activated receptor gamma,[11][7] T-complex 1,[30] HDAC4,[17][18][6][20] CBFA2T3,[32][33] GPS2,[19] YY1,[34][35] RUNX2,[36] GATA1,[37] GATA2,[38] Promyelocytic leukemia protein[39] and Ubiquitin C.[40]

See also


  1. ^ Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (Apr 1998). "Characterization of a human RPD3 ortholog, HDAC3". Proc Natl Acad Sci U S A 95 (6): 2795–800. PMID 9501169.  
  2. ^ Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (Mar 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun 242 (3): 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271.  
  3. ^ "Entrez Gene: HDAC3 histone deacetylase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8841.  
  4. ^ Petrie, Kevin; Guidez Fabien, Howell Louise, Healy Lyn, Waxman Samuel, Greaves Mel, Zelent Arthur (May. 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem. (United States) 278 (18): 16059–72. doi:10.1074/jbc.M212935200. ISSN 0021-9258. PMID 12590135.  
  5. ^ Zhou, X; Richon V M, Rifkind R A, Marks P A (Feb. 2000). "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (3): 1056–61. ISSN 0027-8424. PMID 10655483.  
  6. ^ a b c Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. (United States) 276 (38): 35826–35. doi:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315.  
  7. ^ a b Fajas, Lluis; Egler Viviane, Reiter Raphael, Hansen Jacob, Kristiansen Karsten, Debril Marie-Bernard, Miard Stéphanie, Auwerx Johan (Dec. 2002). "The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation". Dev. Cell (United States) 3 (6): 903–10. ISSN 1534-5807. PMID 12479814.  
  8. ^ Lai, A; Lee J M, Yang W M, DeCaprio J A, Kaelin W G, Seto E, Branton P E (Oct. 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6632–41. ISSN 0270-7306. PMID 10490602.  
  9. ^ Nicolas, E; Ait-Si-Ali S, Trouche D (Aug. 2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein". Nucleic Acids Res. (England) 29 (15): 3131–6. PMID 11470869.  
  10. ^ Li, Guangjin; Franco Peter J, Wei Li-Na (Oct. 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochem. Biophys. Res. Commun. (United States) 310 (2): 384–90. ISSN 0006-291X. PMID 14521922.  
  11. ^ a b c Franco, Peter J; Li Guangjin, Wei Li-Na (Aug. 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Mol. Cell. Endocrinol. (Ireland) 206 (1-2): 1–12. ISSN 0303-7207. PMID 12943985.  
  12. ^ Franco, P J; Farooqui M, Seto E, Wei L N (Aug. 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Mol. Endocrinol. (United States) 15 (8): 1318–28. ISSN 0888-8809. PMID 11463856.  
  13. ^ Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell (United States) 110 (1): 55–67. ISSN 0092-8674. PMID 12150997.  
  14. ^ Shi, Yanhong; Hon Michelle, Evans Ronald M (Mar. 2002). "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2613–8. doi:10.1073/pnas.052707099. ISSN 0027-8424. PMID 11867749.  
  15. ^ Wen, Yu-Der; Cress W Douglas, Roy Ananda L, Seto Edward (Jan. 2003). "Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". J. Biol. Chem. (United States) 278 (3): 1841–7. doi:10.1074/jbc.M206528200. ISSN 0021-9258. PMID 12393887.  
  16. ^ Tussié-Luna, María Isabel; Bayarsaihan Dashzeveg, Seto Edward, Ruddle Frank H, Roy Ananda L (Oct. 2002). "Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (20): 12807–12. doi:10.1073/pnas.192464499. ISSN 0027-8424. PMID 12239342.  
  17. ^ a b Grozinger, C M; Hassig C A, Schreiber S L (Apr. 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4868–73. ISSN 0027-8424. PMID 10220385.  
  18. ^ a b c d Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric (Jan. 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell (United States) 9 (1): 45–57. ISSN 1097-2765. PMID 11804585.  
  19. ^ a b c d Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell (United States) 9 (3): 611–23. ISSN 1097-2765. PMID 11931768.  
  20. ^ a b Grozinger, C M; Schreiber S L (Jul. 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7835–40. doi:10.1073/pnas.140199597. ISSN 0027-8424. PMID 10869435.  
  21. ^ Chen Lf; Fischle W, Verdin E, Greene W C (Aug. 2001). "Duration of nuclear NF-kappaB action regulated by reversible acetylation". Science (United States) 293 (5535): 1653–7. doi:10.1126/science.1062374. ISSN 0036-8075. PMID 11533489.  
  22. ^ Mahlknecht, Ulrich; Will Jutta, Varin Audrey, Hoelzer Dieter, Herbein Georges (Sep. 2004). "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression". J. Immunol. (United States) 173 (6): 3979–90. ISSN 0022-1767. PMID 15356147.  
  23. ^ a b Guenther, M G; Lane W S, Fischle W, Verdin E, Lazar M A, Shiekhattar R (May. 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. (UNITED STATES) 14 (9): 1048–57. ISSN 0890-9369. PMID 10809664.  
  24. ^ a b c Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell (United States) 12 (3): 723–34. ISSN 1097-2765. PMID 14527417.  
  25. ^ a b Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. (England) 22 (6): 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMID 12628926.  
  26. ^ a b Li, J; Wang J, Wang J, Nawaz Z, Liu J M, Qin J, Wong J (Aug. 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. (ENGLAND) 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. ISSN 0261-4189. PMID 10944117.  
  27. ^ a b Underhill, C; Qutob M S, Yee S P, Torchia J (Dec. 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem. (UNITED STATES) 275 (51): 40463–70. doi:10.1074/jbc.M007864200. ISSN 0021-9258. PMID 11013263.  
  28. ^ Petre-Draviam, Christin E; Williams Erin B, Burd Craig J, Gladden Andrew, Moghadam Hamed, Meller Jaroslaw, Diehl J Alan, Knudsen Karen E (Jan. 2005). "A central domain of cyclin D1 mediates nuclear receptor corepressor activity". Oncogene (England) 24 (3): 431–44. doi:10.1038/sj.onc.1208200. ISSN 0950-9232. PMID 15558026.  
  29. ^ Lin, Huei-Min; Zhao Li, Cheng Sheue-Yann (Aug. 2002). "Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors". J. Biol. Chem. (United States) 277 (32): 28733–41. doi:10.1074/jbc.M203380200. ISSN 0021-9258. PMID 12048199.  
  30. ^ a b Guenther, Matthew G; Yu Jiujiu, Kao Gary D, Yen Tim J, Lazar Mitchell A (Dec. 2002). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. (United States) 16 (24): 3130–5. doi:10.1101/gad.1037502. ISSN 0890-9369. PMID 12502735.  
  31. ^ Vaute, Olivier; Nicolas Estelle, Vandel Laurence, Trouche Didier (Jan. 2002). "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids Res. (England) 30 (2): 475–81. PMID 11788710.  
  32. ^ Hoogeveen, André T; Rossetti Stefano, Stoyanova Violeta, Schonkeren Joris, Fenaroli Angelia, Schiaffonati Luisa, van Unen Leontine, Sacchi Nicoletta (Sep. 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene (England) 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. ISSN 0950-9232. PMID 12242670.  
  33. ^ Amann, J M; Nip J, Strom D K, Lutterbach B, Harada H, Lenny N, Downing J R, Meyers S, Hiebert S W (Oct. 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. (United States) 21 (19): 6470–83. ISSN 0270-7306. PMID 11533236.  
  34. ^ Yang, W M; Yao Y L, Sun J M, Davie J R, Seto E (Oct. 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". J. Biol. Chem. (UNITED STATES) 272 (44): 28001–7. ISSN 0021-9258. PMID 9346952.  
  35. ^ Yao, Y L; Yang W M, Seto E (Sep. 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell. Biol. (United States) 21 (17): 5979–91. ISSN 0270-7306. PMID 11486036.  
  36. ^ Schroeder, Tania M; Kahler Rachel A, Li Xiaodong, Westendorf Jennifer J (Oct. 2004). "Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation". J. Biol. Chem. (United States) 279 (40): 41998–2007. doi:10.1074/jbc.M403702200. ISSN 0021-9258. PMID 15292260.  
  37. ^ Watamoto, Kouichi; Towatari Masayuki, Ozawa Yukiyasu, Miyata Yasuhiko, Okamoto Mitsunori, Abe Akihiro, Naoe Tomoki, Saito Hidehiko (Dec. 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene (England) 22 (57): 9176–84. doi:10.1038/sj.onc.1206902. ISSN 0950-9232. PMID 14668799.  
  38. ^ Ozawa, Y; Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (Oct. 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood (United States) 98 (7): 2116–23. ISSN 0006-4971. PMID 11567998.  
  39. ^ Wu, W S; Vallian S, Seto E, Yang W M, Edmondson D, Roth S, Chang K S (Apr. 2001). "The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases". Mol. Cell. Biol. (United States) 21 (7): 2259–68. doi:10.1128/MCB.21.7.2259-2268.2001. ISSN 0270-7306. PMID 11259576.  
  40. ^ Tan, Fengwei; Lu Lifang, Cai Yun, Wang Jinglan, Xie Yunfei, Wang Lin, Gong Yanhua, Xu Bing-E, Wu Jun, Luo Ying, Qiang Boqin, Yuan Jiangang, Sun Xiaoqing, Peng Xiaozhong (Jul. 2008). "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells". Proteomics (Germany) 8 (14): 2885–96. doi:10.1002/pmic.200700887. PMID 18655026.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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