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HES1: Wikis


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Hairy and enhancer of split 1, (Drosophila)
Symbols HES1; FLJ20408; HES-1; HHL; HRY
External IDs OMIM139605 MGI104853 HomoloGene38067 GeneCards: HES1 Gene
RNA expression pattern
PBB GE HES1 203395 s at tn.png
PBB GE HES1 203394 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3280 15205
Ensembl ENSG00000114315 ENSMUSG00000022528
UniProt Q14469 Q3UZZ2
RefSeq (mRNA) NM_005524 XM_001000689
RefSeq (protein) NP_005515 XP_001000689
Location (UCSC) Chr 3:
195.34 - 195.34 Mb
Chr 16:
29.99 - 29.99 Mb
PubMed search [1] [2]

Transcription factor HES-1 is a protein that in humans is encoded by the HES1 gene.[1][2]

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.[2]



HES1 has been shown to interact with TLE2[3] and Sirtuin 1.[4]


  1. ^ Feder JN, Li L, Jan LY, Jan YN (Jul 1994). "Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy". Genomics 20 (1): 56–61. doi:10.1006/geno.1994.1126. PMID 8020957.  
  2. ^ a b "Entrez Gene: HES1 hairy and enhancer of split 1, (Drosophila)".  
  3. ^ Grbavec, D; Lo R, Liu Y, Stifani S (Dec. 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. (GERMANY) 258 (2): 339–49. ISSN 0014-2956. PMID 9874198.  
  4. ^ Takata, Takehiko; Ishikawa Fuyuki (Jan. 2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. (United States) 301 (1): 250–7. ISSN 0006-291X. PMID 12535671.  

Further reading

  • Takebayashi K, Sasai Y, Sakai Y, et al. (1994). "Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.". J. Biol. Chem. 269 (7): 5150–6. PMID 7906273.  
  • Grbavec D, Stifani S (1996). "Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.". Biochem. Biophys. Res. Commun. 223 (3): 701–5. doi:10.1006/bbrc.1996.0959. PMID 8687460.  
  • Ström A, Castella P, Rockwood J, et al. (1998). "Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation.". Genes Dev. 11 (23): 3168–81. doi:10.1101/gad.11.23.3168. PMID 9389649.  
  • Votruba M, Payne A, Moore AT, Bhattacharya SS (1998). "Dominant optic atrophy: exclusion and fine genetic mapping of the candidate gene, HRY.". Mamm. Genome 9 (10): 784–7. doi:10.1007/s003359900867. PMID 9745030.  
  • Bae S, Bessho Y, Hojo M, Kageyama R (2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.". Development 127 (13): 2933–43. PMID 10851137.  
  • Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMID 11238932.  
  • Iso T, Sartorelli V, Poizat C, et al. (2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.". Mol. Cell. Biol. 21 (17): 6080–9. doi:10.1128/MCB.21.17.6080-6089.2001. PMID 11486045.  
  • Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.  
  • Jögi A, Persson P, Grynfeld A, et al. (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation.". J. Biol. Chem. 277 (11): 9118–26. doi:10.1074/jbc.M107713200. PMID 11756408.  
  • Kunisato A, Chiba S, Nakagami-Yamaguchi E, et al. (2003). "HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo.". Blood 101 (5): 1777–83. doi:10.1182/blood-2002-07-2051. PMID 12406868.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Takata T, Ishikawa F (2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.". Biochem. Biophys. Res. Commun. 301 (1): 250–7. doi:10.1016/S0006-291X(02)03020-6. PMID 12535671.  
  • Gratton MO, Torban E, Jasmin SB, et al. (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMID 12972610.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Thomsen JS, Kietz S, Ström A, Gustafsson JA (2004). "HES-1, a novel target gene for the aryl hydrocarbon receptor.". Mol. Pharmacol. 65 (1): 165–71. doi:10.1124/mol.65.1.165. PMID 14722248.  
  • Kamakura S, Oishi K, Yoshimatsu T, et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153.  
  • Persson P, Stockhausen MT, Påhlman S, Axelson H (2005). "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells.". Int. J. Oncol. 25 (5): 1213–21. PMID 15492808.  
  • Aguilera C, Hoya-Arias R, Haegeman G, et al. (2004). "Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16537–42. doi:10.1073/pnas.0404429101. PMID 15536134.  
  • Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.". Mol. Cell 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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