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HES6: Wikis


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Hairy and enhancer of split 6 (Drosophila)
Symbols HES6;
External IDs OMIM610331 MGI1859852 HomoloGene23111 GeneCards: HES6 Gene
RNA expression pattern
PBB GE HES6 gnf1h00306 at tn.png
More reference expression data
Species Human Mouse
Entrez 55502 55927
Ensembl ENSG00000144485 ENSMUSG00000067071
UniProt Q96HZ4 Q9JHE6
RefSeq (mRNA) NM_018645 NM_019479
RefSeq (protein) NP_061115 NP_062352
Location (UCSC) Chr 2:
238.81 - 238.81 Mb
Chr 1:
93.24 - 93.24 Mb
PubMed search [1] [2]

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[1][2]



HES6 has been shown to interact with TLE1.[3]


  1. ^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development 127 (13): 2933–43. PMID 10851137.  
  2. ^ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".  
  3. ^ Gao, X; Chandra T, Gratton M O, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep. 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. (United States) 154 (6): 1161–71. doi:10.1083/jcb.200104058. ISSN 0021-9525. PMID 11551980.  

Further reading

  • Bech P, Bolwig TG, Dein E, et al. (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale.". Acta Psychiatrica Scandinavica 52 (1): 1–6. doi:10.1111/j.1600-0447.1975.tb00017.x. PMID 1155198.  
  • Vasiliauskas D, Stern CD (2001). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors.". Mech. Dev. 98 (1-2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617.  
  • Gao X, Chandra T, Gratton MO, et al. (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program.". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMID 11551980.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array.". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.  
  • Gratton MO, Torban E, Jasmin SB, et al. (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMID 12972610.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation.". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.  
  • Ball AJ, Abrahamsson AE, Tyrberg B, et al. (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMID 17300753.  
  • Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle.". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. PMID 17301032.  
  • Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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