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HES6: Wikis

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Hairy and enhancer of split 6 (Drosophila)
Identifiers
Symbols HES6;
External IDs OMIM610331 MGI1859852 HomoloGene23111 GeneCards: HES6 Gene
RNA expression pattern
PBB GE HES6 gnf1h00306 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55502 55927
Ensembl ENSG00000144485 ENSMUSG00000067071
UniProt Q96HZ4 Q9JHE6
RefSeq (mRNA) NM_018645 NM_019479
RefSeq (protein) NP_061115 NP_062352
Location (UCSC) Chr 2:
238.81 - 238.81 Mb
Chr 1:
93.24 - 93.24 Mb
PubMed search [1] [2]

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[1][2]

Contents

Interactions

HES6 has been shown to interact with TLE1.[3]

References

  1. ^ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development 127 (13): 2933–43. PMID 10851137.  
  2. ^ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55502.  
  3. ^ Gao, X; Chandra T, Gratton M O, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep. 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. (United States) 154 (6): 1161–71. doi:10.1083/jcb.200104058. ISSN 0021-9525. PMID 11551980.  

Further reading

  • Bech P, Bolwig TG, Dein E, et al. (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale.". Acta Psychiatrica Scandinavica 52 (1): 1–6. doi:10.1111/j.1600-0447.1975.tb00017.x. PMID 1155198.  
  • Vasiliauskas D, Stern CD (2001). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors.". Mech. Dev. 98 (1-2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617.  
  • Gao X, Chandra T, Gratton MO, et al. (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program.". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMID 11551980.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array.". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.  
  • Gratton MO, Torban E, Jasmin SB, et al. (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMID 12972610.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation.". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.  
  • Ball AJ, Abrahamsson AE, Tyrberg B, et al. (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMID 17300753.  
  • Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle.". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. PMID 17301032.  
  • Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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