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Hairy/enhancer-of-split related with YRPW motif 1

PDB rendering based on 2db7.
Available structures
Symbols HEY1; CHF2; HERP2; HESR1; HRT-1; MGC1274; OAF1
External IDs OMIM602953 MGI1341800 HomoloGene7756 GeneCards: HEY1 Gene
RNA expression pattern
PBB GE HEY1 44783 s at tn.png
PBB GE HEY1 218839 at tn.png
More reference expression data
Species Human Mouse
Entrez 23462 15213
Ensembl ENSG00000164683 ENSMUSG00000040289
UniProt Q9Y5J3 Q9D0R0
RefSeq (mRNA) NM_001040708 NM_010423
RefSeq (protein) NP_001035798 NP_034553
Location (UCSC) Chr 8:
80.84 - 80.84 Mb
Chr 3:
8.65 - 8.65 Mb
PubMed search [1] [2]

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.[1][2][3]

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]


  1. ^ Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1-2): 173-7. PMID 10415358.  
  2. ^ Kokubo H, Lun Y, Johnson RL (Aug 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochem Biophys Res Commun 260 (2): 459-65. doi:10.1006/bbrc.1999.0880. PMID 10403790.  
  3. ^ a b "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1".  

Further reading

  • Iso T, Kedes L, Hamamori Y (2003). "HES and HERP families: multiple effectors of the Notch signaling pathway.". J. Cell. Physiol. 194 (3): 237–55. doi:10.1002/jcp.10208. PMID 12548545.  
  • Kokubo H, Miyagawa-Tomita S, Johnson RL (2006). "Hesr, a mediator of the Notch signaling, functions in heart and vessel development.". Trends Cardiovasc. Med. 15 (5): 190–4. doi:10.1016/j.tcm.2005.05.005. PMID 16165016.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Chin MT, Maemura K, Fukumoto S, et al. (2000). "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.". J. Biol. Chem. 275 (9): 6381–7. doi:10.1074/jbc.275.9.6381. PMID 10692439.  
  • Steidl C, Leimeister C, Klamt B, et al. (2000). "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.". Genomics 66 (2): 195–203. doi:10.1006/geno.2000.6200. PMID 10860664.  
  • Maier MM, Gessler M (2000). "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.". Biochem. Biophys. Res. Commun. 275 (2): 652–60. doi:10.1006/bbrc.2000.3354. PMID 10964718.  
  • Nakagawa O, McFadden DG, Nakagawa M, et al. (2001). "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13655–60. doi:10.1073/pnas.250485597. PMID 11095750.  
  • Sun J, Kamei CN, Layne MD, et al. (2001). "Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2.". J. Biol. Chem. 276 (21): 18591–6. doi:10.1074/jbc.M101163200. PMID 11279181.  
  • Iso T, Sartorelli V, Chung G, et al. (2001). "HERP, a new primary target of Notch regulated by ligand binding.". Mol. Cell. Biol. 21 (17): 6071–9. doi:10.1128/MCB.21.17.6071-6079.2001. PMID 11486044.  
  • Taylor KL, Henderson AM, Hughes CC (2003). "Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression.". Microvasc. Res. 64 (3): 372–83. doi:10.1006/mvre.2002.2443. PMID 12453432.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Elagib KE, Xiao M, Hussaini IM, et al. (2004). "Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.". Mol. Cell. Biol. 24 (17): 7779–94. doi:10.1128/MCB.24.17.7779-7794.2004. PMID 15314183.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kokubo H, Miyagawa-Tomita S, Nakazawa M, et al. (2005). "Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system.". Dev. Biol. 278 (2): 301–9. doi:10.1016/j.ydbio.2004.10.025. PMID 15680351.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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